Document Detail

Plasma phospholipid fatty acid composition in ischemic stroke: Importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis.
MedLine Citation:
PMID:  23044095     Owner:  NLM     Status:  Publisher    
OBJECTIVE: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. METHODS: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. RESULTS: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. CONCLUSION: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.
Yong-Jae Kim; Oh Yoen Kim; Yoonsu Cho; Ji Hyung Chung; Young-Sang Jung; Geum-Sook Hwang; Min-Jeong Shin
Related Documents :
25238165 - Pomegranate seed oil: effect on 3-nitropropionic acid-induced neurotoxicity in pc12 cel...
25294875 - Changes in transcription and metabolism during the early stage of replicative cellular ...
25207885 - Review on anti-tumor effect of triterpene acid compounds.
3560535 - Comparison of pancreatic exocrine secretion via endogenous secretin by intestinal infus...
2040395 - Prevention of inhibitory effect of free fatty acids on insulin binding and action in is...
1275895 - A study of the supposed hydroxylation of tyrosine catalysed by peroxidase.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-20
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Department of Neurology, Ewha Womans University, Seoul, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Establishment of an In Vitro Photoallergy Test Using NCTC2544 Cells and IL-18 Production.
Next Document:  Defensive coping and subclinical vascular disease risk - Associations with autonomic exhaustion in A...