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Plasma phospholipid fatty acid composition and estimated desaturase activity in heart failure patients with metabolic syndrome.
MedLine Citation:
PMID:  22962535     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Metabolic syndrome is one of the major factors to increase the incidence of heart failure. In our study, we compared plasma fatty acid compositions among heart failure patients with and without Metabolic syndrome. Fatty acid (FA) composition of plasma phospholipids was analyzed and the activities of desaturase were estimated as the ratio of substrate and product fatty acids in 85 stable heart failure patients. Fatty acid and estimated desaturase activities were further examined for their associations with Metabolic syndrome components. Heart failure patients with Metabolic syndrome showed significant changes in fatty acid composition in comparison to those without Metabolic syndrome, which had a decreased proportion of lauric acid (C12:0) and an increased proportion of dihomo-γ-linolenic acid (C20:3n-6). Also, estimated desaturase activities (D5D and D6D) were closely related to Metabolic syndrome condition among heart failure patients. The content of dihomo-γ-linolenic acid showed positive correlations with BMI, waist circumference, and plasma triglyceride levels. D6D were positively associated with plasma triglyceride levels, whereas D5D showed a negative correlation with plasma triglyceride levels and waist circumferences. The content of dihomo-γ-linolenic acid as well as estimated D6D and D5D were altered in heart failure patients with Metabolic syndrome.
Authors:
Seungmin Lee; Hyun Ju Do; Seok-Min Kang; Ji Hyung Chung; Eunju Park; Min-Jeong Shin
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Publication Detail:
Type:  Journal Article     Date:  2012-07-06
Journal Detail:
Title:  Journal of clinical biochemistry and nutrition     Volume:  51     ISSN:  1880-5086     ISO Abbreviation:  J Clin Biochem Nutr     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-10     Completed Date:  2012-09-11     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8700907     Medline TA:  J Clin Biochem Nutr     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  150-5     Citation Subset:  -    
Affiliation:
Department of Food and Nutrition and Institute of Health Science, Korea University, Seoul, Republic of Korea.
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