Document Detail


Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration.
MedLine Citation:
PMID:  9245964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate distribution and excretion of mangafodipir (MnDPDP, Teslascan) in the rat and dog. MATERIAL AND METHODS: Formulations of either 14C-MnDPDP or 54MnDPDP were injected intravenously at near clinical doses in rats and dogs. RESULTS: The manganese (Mn) moiety is rapidly removed from plasma with an elimination half-life of less than 25 min in both species, reflecting a rapid distribution to the tissues and an early excretion. The plasma clearance of the DPDP moiety is slower than that of Mn and it appears to distribute into the extracellular fluid. Mn is distributed largely to the liver, pancreas and kidneys, and in pregnant rats, also to foetal liver and bones. No transplacental passage of DPDP could be detected. The metal is mainly excreted by the faecal route, with a small fraction eliminated early in the urine. DPDP is rapidly and essentially completely excreted in the urine, consistent with the glomerular filtration rate. CONCLUSION: The ligand does not appear to facilitate the transport of Mn into any organ except the kidney for subsequent excretion, and it reduces distribution to the heart. The Mn is taken up by those organs indicated for MR imaging, primarily liver and pancreas.
Authors:
S O Hustvedt; D Grant; T E Southon; K Zech
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  38     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-28     Completed Date:  1997-08-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  690-9     Citation Subset:  IM    
Affiliation:
Nycomed Imaging AS, Oslo, Norway. sohu@nycomed.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Radioisotopes
Contrast Media / administration & dosage,  metabolism*,  pharmacokinetics*
Dogs
Edetic Acid / administration & dosage,  analogs & derivatives*,  metabolism,  pharmacokinetics
Female
Half-Life
Injections, Intravenous
Ligands
Male
Manganese / administration & dosage,  metabolism*,  pharmacokinetics*
Pregnancy
Pyridoxal Phosphate / administration & dosage,  analogs & derivatives*,  metabolism,  pharmacokinetics
Radioisotopes
Rats
Rats, Sprague-Dawley
Time Factors
Tissue Distribution
Whole-Body Counting
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Contrast Media; 0/Ligands; 0/Radioisotopes; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid; 7439-96-5/Manganese

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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