Document Detail


Plasma oxypurinol concentration in a patient with allopurinol hypersensitivity.
MedLine Citation:
PMID:  2528636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monitoring of plasma oxypurinol has been proposed to prevent allopurinol side effects. An 89-year-old man developed a severe desquamative rash, fever, eosinophilia, hepatocellular injury and renal failure after allopurinol administration. Eight hours after the last dose, plasma allopurinol was undetectable and plasma oxypurinol was 50 mumol/l. This is the first case in which severe allopurinol hypersensitivity occurred despite a simultaneous plasma oxypurinol concentration within recommended levels (below 100 mumol/l).
Authors:
J G Puig; E A Casas; T H Ramos; A A Michán; F A Mateos
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  16     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-10-18     Completed Date:  1989-10-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  842-4     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Universidad Autónoma, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Allopurinol / adverse effects*,  metabolism,  therapeutic use
Dermatitis, Exfoliative / chemically induced*
Drug Eruptions / etiology*
Drug Hypersensitivity*
Drug-Induced Liver Injury
Humans
Kidney Failure, Chronic / chemically induced
Male
Oxypurinol / blood*
Pyrimidines / blood*
Chemical
Reg. No./Substance:
0/Pyrimidines; 2465-59-0/Oxypurinol; 315-30-0/Allopurinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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