Document Detail

Plasma oxypurinol concentration in a patient with allopurinol hypersensitivity.
MedLine Citation:
PMID:  2528636     Owner:  NLM     Status:  MEDLINE    
Monitoring of plasma oxypurinol has been proposed to prevent allopurinol side effects. An 89-year-old man developed a severe desquamative rash, fever, eosinophilia, hepatocellular injury and renal failure after allopurinol administration. Eight hours after the last dose, plasma allopurinol was undetectable and plasma oxypurinol was 50 mumol/l. This is the first case in which severe allopurinol hypersensitivity occurred despite a simultaneous plasma oxypurinol concentration within recommended levels (below 100 mumol/l).
J G Puig; E A Casas; T H Ramos; A A Michán; F A Mateos
Related Documents :
24862526 - Intoxication mortelle après ingestion accidentelle de xylocaine visqueuse à 2% chez une...
4335446 - Effect of magnesium depletion on responsiveness to parathyroid hormone in parathyroidec...
8064176 - Biomphalaria glabrata hemolymph lectins: binding to bacteria, mammalian erythrocytes, a...
12361116 - Fluoride concentrations in thoroughbred horses in india.
10230556 - Alteration in plasma antioxidant capacity in various degrees of chronic renal failure.
14761686 - Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproductio...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  16     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-10-18     Completed Date:  1989-10-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  842-4     Citation Subset:  IM    
Department of Internal Medicine, Universidad Autónoma, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Allopurinol / adverse effects*,  metabolism,  therapeutic use
Dermatitis, Exfoliative / chemically induced*
Drug Eruptions / etiology*
Drug Hypersensitivity*
Drug-Induced Liver Injury
Kidney Failure, Chronic / chemically induced
Oxypurinol / blood*
Pyrimidines / blood*
Reg. No./Substance:
0/Pyrimidines; 2465-59-0/Oxypurinol; 315-30-0/Allopurinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Myocardial involvement in Churg-Strauss syndrome: the role of endomyocardial biopsy.
Next Document:  Atrial natriuretic factor: implications in congestive heart failure and hypertension.