| Plasma omega 3 polyunsaturated fatty acid status and monounsaturated fatty acids are altered by chronic social stress and predict endocrine responses to acute stress in titi monkeys. | |
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MedLine Citation:
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PMID: 21211954 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Disturbances in fatty acid (FA) metabolism may link chronic psychological stress, endocrine responsiveness, and psychopathology. Therefore, lipid metabolome-wide responses and their relationships with endocrine (cortisol, insulin, and adiponectin) responsiveness to acute stress (AS) were assessed in a primate model of chronic social stress (CS). Compared to controls (not exposed to CS), CS increased (P≤0.05) circulating triacylglycerol (TG) and phosphatidylethanolamine (PE) n-6/n-3 and reduced (P≤0.05) cholesterol ester (CE) 16:1n7 and phosphatidylcholine (PC) 18:1n7, suggesting lower omega-3 FA status and stearoyl-CoA desaturase activity, respectively. Cortisol responses to AS positively correlated with TG n-6/n-3 (r=0.93; P=0.007), but only in CS monkeys. The adiponectin response to AS inversely correlated with CE n-6/n3 (r=-0.89; P=0.045) and positively with TG 16:1n7 (r=0.98; P=0.004), only in CS monkeys. Our results are consistent with previously reported FA profiles in stress-related psychopathology and suggest that compositional changes of specific lipid FAs may form new functional markers of chronic psychological stress. |
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Authors:
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K D Laugero; J T Smilowitz; J B German; M R Jarcho; S P Mendoza; K L Bales |
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Publication Detail:
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Type: Journal Article Date: 2011-01-05 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 84 ISSN: 1532-2823 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 71-8 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ltd. |
Affiliation:
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Obesity and Metabolism Research Unit, Western Human Nutrition Research Center/ARS/USDA, Davis, CA 95616, USA; Department of Nutrition, UC Davis, Davis, CA 95616, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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