Document Detail


Plasma noradrenaline and the pressor action of exogenous noradrenaline in normotensive subjects and patients with essential hypertension.
MedLine Citation:
PMID:  282099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. An inverse relationship was found between plasma noradrenaline and reactivity to exogenous noradrenaline in normotensive subjects. 2. The relationship between plasma noradrenaline and reactivity was distrubed in age-matched patients with essential hypertension. 3. A multiple-regression analysis showed a highly significant correlation between adrenergic activity and reactivity to noradrenaline and the mean arterial blood pressure level (r = 0.91). The results suggest that adrenergic activity and pressor response to noradrenaline combined are important determinants of arterial blood pressure. 4. An inverse relationship could also be demonstrated between plasma renin activity and reactivity to exogenous angiotensin II. No difference was observed between normotensive and hypertensive subjects.
Authors:
T Philipp; A Distler; U Cordes; H P Wolff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine. Supplement     Volume:  4     ISSN:  0144-4107     ISO Abbreviation:  Clin Sci Mol Med Suppl     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7907311     Medline TA:  Clin Sci Mol Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  61s-63s     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiotensin II / pharmacology
Blood Pressure / drug effects*
Female
Humans
Hypertension / blood*,  physiopathology
Male
Norepinephrine / blood*,  pharmacology
Renin / blood
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 51-41-2/Norepinephrine; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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