Document Detail


Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise training.
MedLine Citation:
PMID:  20620208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma nitrite is a major oxidation product of nitric oxide. It has also recently been suggested to perform an endocrine-like function as a nitric oxide donor in hypoxic tissues, allowing vasodilation. Exercise performance is limited in peripheral arterial disease because of an inadequate blood supply to working tissues. We hypothesized that exercise training in peripheral arterial disease subjects will improve "plasma nitrite flux" and endothelial function, to accompany increased exercise performance. Peripheral arterial disease subjects were tested at baseline and after 3 months supervised or home exercise training. Venous blood (arm) was drawn at rest and 10 min after a maximal graded treadmill test. Samples were added to heparin and centrifuged and plasma was snap-frozen for analysis by reductive chemiluminescence. Brachial artery endothelial function was measured in response to a hyperemic stimulus (flow-mediated dilation). At 3 months the peripheral arterial disease-supervised exercise group showed increases in claudication onset pain time (+138 s, p< or =0.05), peak walking time (+260 s, p< or =0.01), VO(2peak) (1.3 ml/kg/min, p< or =0.05), brachial artery flow-mediated dilation (+2%, p< or =0.05), and plasma nitrite flux (+33% p< or =0.05). There were no changes in the peripheral arterial disease-home exercise group. The change in plasma nitrite flux predicted the change in claudication onset pain (r(2)=0.59, p< or =0.01). These findings suggest that changes in plasma nitrite are related to endothelial function and predict exercise performance in peripheral arterial disease.
Authors:
Jason D Allen; Thomas Stabler; Aarti Kenjale; Katherine L Ham; Jennifer L Robbins; Brian D Duscha; Devon A Dobrosielski; Brian H Annex
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-07-08
Journal Detail:
Title:  Free radical biology & medicine     Volume:  49     ISSN:  1873-4596     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-13     Completed Date:  2011-03-15     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1138-44     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. j.d.allen@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Athletic Performance / physiology
Brachial Artery / pathology
Electrocardiography
Endothelium, Vascular / metabolism*,  pathology
Exercise Test
Exercise Therapy*
Female
Humans
Intermittent Claudication
Luminescent Measurements
Male
Middle Aged
Nitrites / blood
Peripheral Arterial Disease / diagnosis,  pathology,  physiopathology,  therapy*
Prognosis
Vasodilation / physiology
Walking
Grant Support
ID/Acronym/Agency:
R01 HL075752-01/HL/NHLBI NIH HHS; R01 HL755752/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Nitrites
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