Document Detail

Plasma nitric oxide and iron concentrations in exercised rats are negatively correlated.
MedLine Citation:
PMID:  10939641     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the effect of strenuous exercise on plasma nitric oxide and iron (PI) concentrations in rats. The rats were divided into six groups: 3, 6 and 12 months of the exercise (swimming) groups and their corresponding controls. At the end of experimental periods, blood samples were collected to measure plasma NOx (nitrate and nitrite) and iron concentrations and other hematological indices. The correlative analysis of plasma NOx with PI in the exercised and the control rats was performed. The results showed that plasma NOx concentration was significantly greater and PI lower in the 3, 6, and 12 months of the exercise groups compared to their sedentary controls (p < 0.01). However, the duration of strenuous exercise had no significant effect on plasma NOx or PI contents. A negative correlation between plasma NOx and PI levels was found in all three exercise groups (r = -0.750, -0.578, and -0.808 and p < 0.01, 0.05, 0.01 respectively), but not in the sedentary control groups. These results imply that strenuous exercise may lead to an increase in plasma NOx concentration as well as a low iron level. They also suggest the possibility that the increased NO production might be associated with the development of the lower iron status in exercise.
D S Xiao; Z M Qian
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  208     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-11-15     Completed Date:  2000-12-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon.
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MeSH Terms
Iron / blood*
Nitric Oxide / blood*,  metabolism
Physical Conditioning, Animal*
Random Allocation
Rats, Sprague-Dawley
Statistics as Topic
Time Factors
Reg. No./Substance:
0/Hemoglobins; 10102-43-9/Nitric Oxide; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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