Document Detail

Plasma nitrate values in patients with obsessive-compulsive disorder.
MedLine Citation:
PMID:  16194270     Owner:  NLM     Status:  MEDLINE    
Recently there has been increasing evidence that free oxygen species may play an important role in the pathophysiology of various neuropsychiatric disorders. The present study was performed to assess the changes in plasma nitric oxide (NO) levels in patients with obsessive-compulsive disorder (OCD) compared to age- and sex-matched normal controls. Twenty-three patients with OCD and 23 healthy volunteers were included in the study. NO values were determined in the plasma of normal healthy controls and the OCD patients. Plasma nitrate levels in OCD patients were significantly higher than those in controls and were significantly and positively correlated with Yale-Brown Obsession Compulsion Scale scores but not related to age or to the duration of illness. These findings indicated a possible role of increased NO may be relevant to the pathophysiology of OCD.
Murad Atmaca; Ertan Tezcan; Murat Kuloglu; Bilal Ustundag
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  59     ISSN:  1323-1316     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-30     Completed Date:  2006-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  621-3     Citation Subset:  IM    
Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey.
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MeSH Terms
Aging / metabolism
Nitrates / blood*
Nitric Oxide / blood*
Obsessive-Compulsive Disorder / blood*
Psychiatric Status Rating Scales
Reg. No./Substance:
0/Nitrates; 10102-43-9/Nitric Oxide

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