Document Detail


Plasma neutral amino acid ratios in normal man and in patients with hepatic encephalopathy: correlations with self-selected protein and energy consumption.
MedLine Citation:
PMID:  6111214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma amino acid concentrations and the ratios of tryptophan and tyrosine to other large neutral amino acids (NAA) were related to prior food consumption by normal healthy adults and by adults with hepatic encephalopathy. Previous habitual (3-day) energy consumption by 32 healthy subjects correlated inversely with the fasting plasma tyr/NAA (r = --0.40, p less than 0.05), while the proportion of energy consumed as protein was inversely related to plasma trp/NAA (r = -0.63, p less than 0.001). Postprandial plasma trp/NAA of 11 normal subjects at 2 and 4 h also reflected (r = --0.62 and --0.69, p less than 0.05, respectively) the proportion of food energy chosen as protein at a single meal. Similarly, samples obtained from five patients with hepatic encephalopathy showed that when high plasma trp/NAA ratios occur these are likely to be due to the low protein intake prescribed. However, for these patients the tyr/NAA or the tyr and met/branched-chain amino acid ratios were above normal ranges caused by diet. The conclusion of this study is that the plasma trp/NAA ratio is associated with the proportion of dietary energy consumed as protein, whereas the plasma tyr/NAA ratio is associated with long-term total energy consumption.
Authors:
G H Anderson; L M Blendis
Related Documents :
3760054 - Microanalysis of free fatty acids in plasma of experimental animals and humans by high-...
7266724 - Ascorbate-cyanide test on red blood cells in uremia: effect of guanidinopropionic acid.
2055054 - Lipolytic response to metabolic stress in critically ill patients.
11237944 - Plasma free amino acid concentrations in healthy guatemalan adults and in patients with...
24108064 - Cell-free cartilage engineering approach using hyaluronic acid-polycaprolactone scaffol...
3917984 - Hapten-specific prophylaxis of murine contact sensitivity by dnp-amino acid derivatives.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  34     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  377-85     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amino Acids / blood*
Amino Acids, Branched-Chain / blood
Diet*
Diet, Vegetarian
Dietary Proteins / administration & dosage*
Energy Intake
Feeding Behavior
Female
Food Habits
Hepatic Encephalopathy / blood,  metabolism*
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Neurotransmitter Agents / metabolism
Tryptophan / blood
Tyrosine / blood
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Branched-Chain; 0/Dietary Proteins; 0/Neurotransmitter Agents; 55520-40-6/Tyrosine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term benefit of cardioselective beta blockade with once-daily atenolol therapy in angina pector...
Next Document:  Techniques of administration of metered-dose aerosolized drugs in asthmatic children.