Document Detail

Plasma neutral amino acid ratios in normal man and in patients with hepatic encephalopathy: correlations with self-selected protein and energy consumption.
MedLine Citation:
PMID:  6111214     Owner:  NLM     Status:  MEDLINE    
Plasma amino acid concentrations and the ratios of tryptophan and tyrosine to other large neutral amino acids (NAA) were related to prior food consumption by normal healthy adults and by adults with hepatic encephalopathy. Previous habitual (3-day) energy consumption by 32 healthy subjects correlated inversely with the fasting plasma tyr/NAA (r = --0.40, p less than 0.05), while the proportion of energy consumed as protein was inversely related to plasma trp/NAA (r = -0.63, p less than 0.001). Postprandial plasma trp/NAA of 11 normal subjects at 2 and 4 h also reflected (r = --0.62 and --0.69, p less than 0.05, respectively) the proportion of food energy chosen as protein at a single meal. Similarly, samples obtained from five patients with hepatic encephalopathy showed that when high plasma trp/NAA ratios occur these are likely to be due to the low protein intake prescribed. However, for these patients the tyr/NAA or the tyr and met/branched-chain amino acid ratios were above normal ranges caused by diet. The conclusion of this study is that the plasma trp/NAA ratio is associated with the proportion of dietary energy consumed as protein, whereas the plasma tyr/NAA ratio is associated with long-term total energy consumption.
G H Anderson; L M Blendis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  34     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  377-85     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acids / blood*
Amino Acids, Branched-Chain / blood
Diet, Vegetarian
Dietary Proteins / administration & dosage*
Energy Intake
Feeding Behavior
Food Habits
Hepatic Encephalopathy / blood,  metabolism*
Hydrogen-Ion Concentration
Middle Aged
Neurotransmitter Agents / metabolism
Tryptophan / blood
Tyrosine / blood
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Branched-Chain; 0/Dietary Proteins; 0/Neurotransmitter Agents; 55520-40-6/Tyrosine; 73-22-3/Tryptophan

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