Document Detail

Plasma neurotransmitters throughout an oral glucose tolerance test in non-depressed essential hypertension patients.
MedLine Citation:
PMID:  8096777     Owner:  NLM     Status:  MEDLINE    
The oral glucose tolerance test (OGTT) with plasma neurotransmitter assays and blood pressure measurements were performed on 68 hypertensive (A and B) and 68 paired normal controls (group C). Those patients who failed to show significant or persistent blood pressure reductions throughout OGTT constitute group A (37 subjects); and those who did show significant and persistent reductions constitute group B (31 subjects). The purpose of this study was to assess if there were any significant differences between those patients whose blood pressure levels normalized throughout OGTT and those who didn't and, further, compare them to their controls. In group A, noradrenaline (NA) was high at the 0' (fasting) period, increasing further at 60' and 90'; however, circulating serotonin (p5HT) did not vary throughout OGTT. Group B, although showing high NA at 0', did not show rises afterwards; whereas, significant and sustained p5HT rises registered throughout postprandial periods. In group C, both p5HT and plasma NA showed significant and sustained increases. Therefore, the NA/p5HT ratio is higher in A, than in B and C. Group A patients were awake and alert throughout. Group B patients were mostly drowsy and many slept light and intermittently. Group C subjects slept throughout, dreaming and showing rapid eye movements. Our findings suggest that the hypertensive syndrome is most severe in those patients who do not show a rise in postprandial circulating serotonin (parasympathetic activity), group A, than those who do exhibit such a rise, group B.
F Lechín; B van der Dijs; M Lechín; H Jara; A Lechín; S Báez; B Orozco; I Rada; A Cabrera; L Arocha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  15     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-05-11     Completed Date:  1993-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-40     Citation Subset:  IM    
Department of Physiopathology and General Pathology, Instituto de Medicina Experimental, Universidad Central de Venezuela.
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MeSH Terms
Blood Pressure / physiology
Dopamine / blood
Epinephrine / blood
Glucose Tolerance Test
Hypertension / blood*,  physiopathology,  psychology
Middle Aged
Neurotransmitter Agents / blood*
Norepinephrine / blood
Serotonin / blood
Time Factors
Reg. No./Substance:
0/Neurotransmitter Agents; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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