Document Detail

Plasma neuropeptide Y on admission to a coronary care unit: raised levels in patients with left heart failure.
MedLine Citation:
PMID:  2328516     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE - The aim of the study was to measure plasma neuropeptide Y, which is related to sympathetic nerve stimulation, in patients admitted to a coronary care unit and to relate the findings to clinical information. DESIGN - Plasma neuropeptide Y was measured on admission and the results were related to the cause of admission and to clinical information collected prospectively and retrospectively. SUBJECTS - Plasma subjects were obtained from 377 consecutive daytime admissions to the coronary care unit at Södersjukhuset. Results of only the first sample in each patient are included in this study, so 45 cases observed more than once (readmitted patients) were omitted. Six samples were abandoned because of technical failures. The study therefore comprises 326 patients. Clinical diagnoses were defined as acute myocardial infarction, arrhythmia, angina pectoris, and miscellaneous (all other diagnoses). Heart failure was defined according to a modified Killip scheme. MEASUREMENTS and RESULTS - Neuropeptide Y like immunoreactivity was measured by radio-immunoassay. Plasma concentrations above normal (greater than 30 pmol.litre-1) were found in association with: increased age, female sex, diuretic treatment, tachycardia, arterial hypotension, increased respiratory rate, and mortality in the unit. There was a strong relationship between high neuropeptide Y concentrations and: moderate left heart failure (63%), pulmonary oedema (90%), and cardiogenic shock (100%). Of patients without heart failure only 25% had raised neuropeptide Y. In multivariate analysis, the severity of heart failure (Killip class), heart rate and respiratory rate were the only variables that were significantly and independently related to plasma neuropeptide Y. CONCLUSIONS - The presence and degree of circulatory disturbance, in particular tachycardia and left heart failure, were strongly related to increased plasma concentrations of neuropeptide Y in coronary care patients.
J Hulting; A Sollevi; B Ullman; A Franco-Cereceda; J M Lundberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  24     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-30     Completed Date:  1990-05-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  IM    
Department of Medicine I, Södersjukhuset, Stockholm, Sweden.
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MeSH Terms
Aged, 80 and over
Angina Pectoris / blood
Arrhythmias, Cardiac / blood
Coronary Care Units
Diuretics / administration & dosage
Epinephrine / blood
Heart Failure / blood*
Middle Aged
Myocardial Infarction / blood
Neuropeptide Y / blood*
Norepinephrine / blood
Pilot Projects
Pulmonary Edema / blood
Risk Factors
Shock, Cardiogenic / blood
Reg. No./Substance:
0/Diuretics; 0/Neuropeptide Y; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

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