| Plasma natriuretic peptide levels and daily physical activity in patients with pacemaker implantation. | |
MedLine Citation:
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PMID: 11693283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether plasma ANP and/or BNP levels can be used to detect limitations in daily physical activity after pacemaker implantation, we measured plasma ANP and BNP levels at a pacemaker follow-up clinic in 56 patients (62+/-15 yrs, 2AAI, 9VVI, 34DDD, 7VDD and 4 rate-responsive modes), daily physical activity evaluated by a specific activity scale questionnaire (METs) and VO2 max obtained by expired gas analysis during ergometer exercise. A very close correlation (n=6, r=0.89, p<0.05) was obseved between. ANP in patients with daily physical activity class III (2-4 METs, n=21) was significantly higher than class II (5-6 METs, n=23, p<0.01) and class I (>7 METs, n=8, p<0.01), while BNP in class III patients was significantly higher than in class II (p<0.0001) and class I (p<0.0001) patients. Significant correlations between daily physical activity and BNP (r=-0.64, p<0.0001) and ANP (r=-0.43, p<0.001) were observed. Physiological pacing mode did not necessarily offer a better profile for BNP levels compared with non-physiological pacing modes. Patients with ventricular pacing (wide QRS: VDD, RR-VVI and VVI) showed significantly high ANP (p<0.01) and BNP (p<0.01) levels compared with those in patients with atrial pacing (narrow QRS: AAI and RR-AAI). During exercise, plasma catecholamines and ANP levels were significantly elevated, however, BNP levels, which were already elevated at rest, did not change significantly, and reflected a limitation of daily physical activity. The present study revealed that 37.5% of the patients displayed an elevation in BNP and this was judged to be a limitation of physical activity class III being equivalent to NYHA II or more. Elevated resting BNP levels reflected a limitation in daily physical activity in these patients. These findings suggested a third condition for physiological pacing--synchronization of ventricular contraction (narrow QRS pacing)--in addition to the two conventional conditions of atrioventricular synchrony and rate-responsiveness. |
Authors:
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X Wu; Y Seino; H Ogura; N Fukuma; T Katoh; T Takano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese heart journal Volume: 42 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-11-05 Completed Date: 2001-12-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: Japan |
Other Details:
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Languages: eng Pagination: 471-82 Citation Subset: IM |
Affiliation:
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First Department of Medicine, Nippon Medical School, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrial Natriuretic Factor / blood* Catecholamines / blood Electrophysiology Exercise / physiology* Female Heart Block / blood, therapy Humans Male Middle Aged Natriuretic Peptide, Brain / blood* Pacemaker, Artificial* Prospective Studies Sick Sinus Syndrome / blood, therapy |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
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