Document Detail

Plasma natriuretic peptide concentrations as a predictor for successful catheter ablation in patients with drug-refractory atrial fibrillation.
MedLine Citation:
PMID:  17322627     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The concentrations of atrial and brain natriuretic peptides (ANP and BNP) are elevated in patients with atrial fibrillation (AF), but the usefulness of their measurement before and after AF ablation has not been reported. METHODS AND RESULTS: The concentrations of the natriuretic peptides were evaluated in 54 patients undergoing catheter ablation for drug-resistant paroxysmal and persistent AF without heart failure. Based on the outcome, the patients were divided into 2 groups: successful (n=42) or failure (n=12). All patients were asked to keep a log of the duration and frequency of their symptoms and underwent 24-h ECG monitoring at least once after the ablation. The plasma BNP and ANP concentrations, most of which were well below the heart failure range, exceeded the normal range in 69% and 26% of the patients, respectively. The BNP concentration decreased after ablation in the success group (49+/-43 to 27+/-28 pg/ml; p<0.05), however, it was unchanged in the failure group (46+/-35 to 70+/-37 pg/ml; p=0.46). A value of the DeltaBNP (BNP after ablation - BNP before ablation) of </=0 pg/ml identified a successful ablation with a sensitivity of 83% and specificity of 83%. The plasma ANP concentration did not differ statistically between the 2 groups before and after the ablation. CONCLUSION: A moderate elevation in the BNP concentration is often found in patients with symptomatic paroxysmal and persistent AF, and a reduction in the plasma BNP concentration shortly after the ablation may indicate a successful outcome.
Kenji Kurosaki; Hiroshi Tada; Tohru Hashimoto; Sachiko Ito; Kohei Miyaji; Shigeto Naito; Shigeru Oshima; Koichi Taniguchi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
Department of Cardiology, Jichi Medical School, Minamikawachi, Japan.
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MeSH Terms
Atrial Fibrillation / diagnosis,  therapy*
Atrial Natriuretic Factor / blood*
Catheter Ablation / methods*
Drug Resistance
Electrocardiography, Ambulatory
Middle Aged
Natriuretic Peptide, Brain / blood*
Predictive Value of Tests*
Treatment Outcome
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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