Document Detail

Plasma monomeric calcitonin as a marker of disease activity in multiple myeloma patients with osteolysis.
MedLine Citation:
PMID:  1634826     Owner:  NLM     Status:  MEDLINE    
Circulating monomeric human calcitonin (hCT-M), parathyroid hormone, osteocalcin, alkaline phosphatase, urinary hydroxyproline, corrected serum calcium and inorganic phosphate were measured in 49 multiple myeloma patients and 49 matched controls. In patients with Durie-Salmon stage III disease hCT-M levels (16.9 +/- 5.8 ng/l, mean +/- SD) were significantly higher than controls and stage I patients (P less than 0.01), and correlated directly with corrected serum calcium (r = 0.74; P less than 0.001). In the same subgroup 14 of 15 patients had plasma hCT-M concentrations higher than the mean + 2SD of the controls. The calcium infusion test induced an increase of hCT-M in normocalcemic patients which was significantly greater in patients with advanced disease than in either controls or stage I patients. These findings suggest that hCT-M may be a biochemical index of bone resorption and disease activity in myeloma patients with osteolysis. In fact, its plasma concentrations were elevated in a large proportion (93%) of patients with severe bone involvement, and correlated directly with serum calcium. Moreover, our findings suggest the presence of a calcitonin-dependent calcium homeostatic mechanism, that protects against hypercalcemia due to tumor osteolysis.
M Monti; A Scazzoso; M Bevilacqua; I Santi; E D'Aprile; A Saligari; G Norbiato; E Cunietti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of biological markers     Volume:  7     ISSN:  0393-6155     ISO Abbreviation:  Int. J. Biol. Markers     Publication Date:    1992 Apr-Jun
Date Detail:
Created Date:  1992-08-26     Completed Date:  1992-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8712411     Medline TA:  Int J Biol Markers     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
IV Department of Medicine, Geriatric Institute Pio Albergo Trivulzio, Milano, Italy.
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MeSH Terms
Aged, 80 and over
Alkaline Phosphatase / blood
Calcitonin / blood*
Calcium / blood
Hydroxyproline / urine
Middle Aged
Multiple Myeloma / blood*,  complications
Osteocalcin / blood
Osteolysis / blood*,  etiology
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Tumor Markers, Biological; 104982-03-8/Osteocalcin; 51-35-4/Hydroxyproline; 7440-70-2/Calcium; 9007-12-9/Calcitonin; EC Phosphatase

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