| Plasma monocyte chemoattractant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hypertension. | |
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MedLine Citation:
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PMID: 11463608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathogenesis of severe pulmonary hypertension seems to be related to inflammatory response in diseased sites. Monocyte chemoattractant protein-1 (MCP-1) has been reported to play a role in the development of congestive heart failure. In this immunological response, activation and migration of leukocytes including macrophages to the inflammatory region are important factors. We hypothesized that the severity of pulmonary hypertension may be related to MCP-1, which is thought to be upregulated by blood pressure or shear stress in pulmonary vasculature as well as by immunological and inflammatory reactions in chronic thromboembolic pulmonary hypertension (CTEPH). Circulating levels of MCP-1, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) were measured by sandwich ELISA in 14 patients with CTEPH. The plasma level of MCP-1 was significantly correlated with pulmonary vascular resistance. In IL-1beta and TNF-alpha, on the other hand, there was no correlation between cytokines and pulmonary hemodynamics. Pathological specimens obtained from the patients with CTEPH undergoing thromboendarterectomy demonstrated immunoreactivity of MCP-1 in endothelium, smooth muscle cells, and macrophages within neointima in the hypertensive large elastic pulmonary artery. We conclude that MCP-1 is upregulated in the remodeling of pulmonary arteries in close association with increased pulmonary vascular resistance in CTEPH. |
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Authors:
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H Kimura; O Okada; N Tanabe; Y Tanaka; M Terai; Y Takiguchi; M Masuda; N Nakajima; K Hiroshima; H Inadera; K Matsushima; T Kuriyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 164 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-20 Completed Date: 2001-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 319-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Chest Medicine, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8679, Japan. kimura@nmu-gw.naramed-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chemokine CCL2 / blood* Chronic Disease Cytokines / blood Female Hemodynamics Humans Hypertension, Pulmonary / blood*, pathology, physiopathology* Male Middle Aged Pulmonary Artery / pathology, physiopathology* Pulmonary Embolism / blood*, pathology, physiopathology* Vascular Resistance / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL2; 0/Cytokines |
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