Document Detail

Plasma mineralocorticoids, glucocorticoids, and progestins in premature infants: longitudinal study during the first week of life.
MedLine Citation:
PMID:  3387174     Owner:  NLM     Status:  MEDLINE    
Plasma levels of aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol, and cortisone were measured simultaneously by a micromethod of multisteroid analysis in eight vaginally delivered premature infants (PI) of 33-36 wk gestation with uneventful peri- and postnatal course. Mean concentrations (ng/ml) in umbilical arterial and in peripheral venous or capillary plasma sampled longitudinally at age 2 h to 7 days were compared with the same kind of data obtained from a group of 12 term infants (TI) who served as controls. Mean aldosterone was two to five times higher in PI than in TI (umbilical artery, 2 h to 7 days; p less than 0.05), whereas 11-deoxycorticosterone was lower in PI from 2 h (p less than 0.01) until 7 days (NS). Corticosterone was significantly higher in PI than TI at 6 and 24 h after birth, whereas cortisol was slightly lower (NS) in PI in umbilical artery and 2 h after birth, but higher (p less than 0.02) at 6 h, showing less variation in PI than in TI. 17-Hydroxyprogesterone levels in PI were two to three times higher (p less than 0.02) during 6 h until 7 days after birth. The data suggest that PI are able to maintain high aldosterone levels in the early neonatal period. Higher levels of the active glucocorticoids (cortisol and corticosterone) seen after delivery point to a more stressful extrauterine adaptation of PI. Furthermore, the data demonstrate that the adrenal cortex is fully functioning in premature infants (33-36 wk gestation) as well as in term infants.
H G Doerr; W G Sippell; H T Versmold; F Bidlingmaier; D Knorr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  23     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  525-9     Citation Subset:  IM    
Department of Pediatrics, University of Munich, FRG.
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MeSH Terms
Adrenal Cortex / metabolism*
Age Factors
Aldosterone / blood
Gestational Age
Glucocorticoids / blood*
Infant, Newborn
Infant, Premature*
Longitudinal Studies
Mineralocorticoids / blood*
Progestins / blood*
Reg. No./Substance:
0/Glucocorticoids; 0/Mineralocorticoids; 0/Progestins; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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