| Plasma midregional proadrenomedullin (MR-proADM) in newborn infants: Impact of prematurity and perinatal infection. | |
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MedLine Citation:
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PMID: 22447319 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background:Adrenomedullin (ADM) is one of the strongest endogenous vasodilating hormones. Its stable by-product midregional-proADM (MR-proADM) is an established indicator of systemic infection and cardiovascular compromise in adult patients.Methods:A prospective cross-sectional study was performed to investigate perinatal factors affecting MR-proADM plasma concentrations in 328 newborn infants with a gestational age (GA) between 24 and 41 weeks.Results:Blood samples were obtained in 270 infants from umbilical veins (with additional 108 paired samples from umbilical arteries), and at day 2-3 of life in 183 infants. Paired venous and arterial umbilical cord MR-proADM concentrations were closely related (R(s) 0.825, p<0.001). MR-proADM concentrations at birth and at day 2-3 were inversely related to GA (R(s) -0.403 and R(s) -0.541, respectively) and birth weight (R(s) -0.421 and Rs -0.530, respectively; all p<0.001). On stepwise regression analysis, clinical chorioamnionitis and umbilical arterial blood base excess retained a significant impact on MR-proADM cord venous blood concentrations. At days 2-3 of life, histologic chorioamnionitis and GA at delivery were significantly associated with MR-proADM levels.Conclusions:Compared to adults, MR-proADM concentrations are elevated in neonates, especially those born very preterm. Immaturity and infection which both feature low systemic vascular resistance are related to increased MR-proADM concentrations. |
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Authors:
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Deborah Admaty; Jörg Benzing; Tilo Burkhardt; Olav Lapaire; Lukas Hegi; Gabor Szinnai; Nils G Morgenthaler; Hans Ulrich Bucher; Christoph Bührer; Sven Wellmann |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-23 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Neonatology, University Hospital Zürich, CH-8091 Zürich, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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