Document Detail


Plasma metabolomics reveals biomarkers of the atherosclerosis.
MedLine Citation:
PMID:  20730840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in industrialized societies. The lack of metabolite biomarkers has impeded the clinical diagnosis of atherosclerosis so far. In this study, stable atherosclerosis patients (n=16) and age- and sex-matched non-atherosclerosis healthy subjects (n=28) were recruited from the local community (Harbin, P. R. China). The plasma was collected from each study subject and was subjected to metabolomics analysis by GC/MS. Pattern recognition analyses (principal components analysis, orthogonal partial least-squares discriminate analysis, and hierarchical clustering analysis) commonly demonstrated plasma metabolome, which was significantly different from atherosclerotic and non-atherosclerotic subjects. The development of atherosclerosis-induced metabolic perturbations of fatty acids, such as palmitate, stearate, and 1-monolinoleoylglycerol, was confirmed consistent with previous publication, showing that palmitate significantly contributes to atherosclerosis development via targeting apoptosis and inflammation pathways. Altogether, this study demonstrated that the development of atherosclerosis directly perturbed fatty acid metabolism, especially that of palmitate, which was confirmed as a phenotypic biomarker for clinical diagnosis of atherosclerosis.
Authors:
Xi Chen; Lian Liu; Gustavo Palacios; Jie Gao; Ning Zhang; Guang Li; Juan Lu; Ting Song; Yingzhi Zhang; Haitao Lv
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of separation science     Volume:  33     ISSN:  1615-9314     ISO Abbreviation:  J Sep Sci     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088554     Medline TA:  J Sep Sci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2776-83     Citation Subset:  IM    
Affiliation:
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P. R. China.
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / blood*
Biological Markers / blood*
Fatty Acids / blood,  chemistry
Gas Chromatography-Mass Spectrometry / methods
Humans
Metabolomics / methods*
Molecular Structure
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids

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