| Plasma membrane injury induced by nonyl gallate in Saccharomyces cerevisiae. | |
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MedLine Citation:
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PMID: 12010543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The aim was to investigate the antifungal actions of nonyl gallate against Saccharomyces cerevisiae ATCC 7754. METHODS AND RESULTS: The maximum potency of both the growth inhibitory and the fungicidal effect against the yeast strain was found in nonyl gallate among n-alkyl gallates tested. Nonyl gallate induced ROS generation dose-dependently in growing cells. This ester rapidly killed yeast cells even when cell division was restricted by cycloheximide. This ester inhibited glucose-induced medium acidification and promoted the efflux of intracellular potassium ions in a nongrowing condition. Moreover, nonyl gallate induced a leakage of calcein from artificially prepared liposomes to a greater extent than dodecyl gallate did. CONCLUSIONS: These results suggested nonyl gallate injured plasma membrane of S. cerevisiae, resulting in its exhibition of fungicidal effect accompanying with a leakage of intracellular materials from the cells. SIGNIFICANCE AND IMPACT OF THE STUDY: Our study reveals new knowledge on the antifungal actions of nonyl gallate against S. cerevisiae. When nonyl gallate is applied as a food preservative, the level of its addition to foods may be reduced because of its potent antifungal activity compared with weak acids including sorbic acid and benzoic acid. |
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Authors:
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K Fujita; I Kubo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied microbiology Volume: 92 ISSN: 1364-5072 ISO Abbreviation: J. Appl. Microbiol. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-05-15 Completed Date: 2002-07-26 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9706280 Medline TA: J Appl Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 1035-42 Citation Subset: IM |
Affiliation:
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Department of Environmental Science, Policy and Management, University of California, Berkeley, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acids
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metabolism Adsorption Antifungal Agents / pharmacology* Antioxidants / pharmacology Cell Membrane / drug effects* Culture Media / metabolism Cycloheximide / pharmacology Esters / pharmacology Gallic Acid / analogs & derivatives*, pharmacology* Glucose / pharmacology Potassium / metabolism Reactive Oxygen Species / metabolism Saccharomyces cerevisiae / drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Acids; 0/Antifungal Agents; 0/Antioxidants; 0/Culture Media; 0/Esters; 0/Reactive Oxygen Species; 0/nonyl gallate; 1166-52-5/lauryl gallate; 149-91-7/Gallic Acid; 50-99-7/Glucose; 66-81-9/Cycloheximide; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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