| Plasma-mediated vascular dysfunction in the reduced uterine perfusion pressure model of preeclampsia: a microvascular characterization. | |
| | |
MedLine Citation:
|
PMID: 19564546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Preeclampsia is associated with widespread maternal vascular dysfunction, which is thought to be mediated by circulating factor(s). The aim of the study was to characterize vascular function in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia and to investigate the role of plasma factors in mediating any observed changes in vascular reactivity. Mean arterial blood pressure and vascular function were measured in RUPP and control rats. Mesenteric vessels from both virgin and pregnant rats were exposed for 1 hour or overnight to plasma from both RUPP and control rats and their vascular function assessed. RUPP rats were characterized by severe hypertension, restricted fetal growth, and reduced placental weight (P<0.001). Vasorelaxation was impaired in resistance vessels from RUPP compared with control rats (acetylcholine: R(max) 70+/-3 versus 92+/-1 [NP] and 93+/-3% [sham], P<0.01; bradykinin: 40+/-2 versus 62+/-2 [NP] and 59+/-4% [sham], P<0.001). Incubation of vessels from pregnant (but not virgin) animals with RUPP plasma overnight resulted in an attenuation of vasorelaxant responses (acetylcholine: 63+/-7 versus 86+/-2%, P<0.05; bradykinin: 35+/-5 versus 55+/-6%, P<0.001). The residual relaxant response in RUPP plasma-treated vessels was not further attenuated after treatment with N(omega)-nitro-l-arginine methyl ester (acetylcholine: 57+/-7 versus 63+/-7%, ns; bradykinin: 37+/-5 versus 35+/-5%, ns). The RUPP rat model is characterized by an impaired response to vasodilators which may be attributable to one or more circulating factors. This plasma-mediated endothelial dysfunction appears to be a pregnancy-dependent effect. Furthermore, nitric oxide-mediated vasorelaxation appears to be absent in RUPP plasma-treated vessels. |
| | |
Authors:
|
Sarah K Walsh; Fred A English; Edward J Johns; Louise C Kenny |
Related Documents
:
|
10993766 - High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension. 1407016 - An analysis of the inhibitory effects of prazosin on the phenylephrine response curves ... 19703476 - Modification of the effect of nifedipine in the pregnant rat myometrium: the influence ... 10980246 - Functional importance of neuronal nitric oxide synthase in the endothelium of rat basil... 9279936 - Physiological and behavioral effects of chronic intracerebroventricular infusion of cor... 10488056 - Downregulation of soluble guanylyl cyclase in young and aging spontaneously hypertensiv... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-29 |
Journal Detail:
|
Title: Hypertension Volume: 54 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-07-23 Completed Date: 2009-08-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
|
Languages: eng Pagination: 345-51 Citation Subset: IM |
Affiliation:
|
Anu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland. S.Walsh@ucc.ie |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Blood Pressure Determination Disease Models, Animal Endothelium, Vascular / physiology Female Microcirculation / drug effects, physiology* NG-Nitroarginine Methyl Ester / pharmacology* Nitric Oxide / metabolism* Perfusion / methods Placenta / blood supply Pre-Eclampsia / physiopathology* Pregnancy Pressure Probability Random Allocation Rats Rats, Sprague-Dawley Risk Factors Uterus / blood supply* Vasoconstriction / drug effects, physiology Vasodilation / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardiac Renin levels are not influenced by the amount of resident mast cells.
Next Document: Effect of rosuvastatin on cardiac remodeling, function, and progression to heart failure in hyperten...