Document Detail

Plasma and liver cholesterol concentrations in mice fed semipurified diets differing in the amount of cholesterol and type of fat.
MedLine Citation:
PMID:  3804616     Owner:  NLM     Status:  MEDLINE    
Male and female mice of two inbred strains were fed semipurified diets with or without added cholesterol (1%, w/w) containing 18% by weight of either coconut fat or corn oil. After 28 days coconut fat had produced higher concentrations of plasma cholesterol than corn oil in almost all groups, irrespective of whether the diets contained cholesterol or were cholesterol-free. On the cholesterol-free diets, the type of fat did not influence the concentration of liver cholesterol. Dietary cholesterol caused a marked increase in liver cholesterol, the magnitude of the effect being dependent on the strain of mice and being greater in females than males. In all groups fed cholesterol corn oil caused significantly higher concentrations of liver cholesterol than coconut fat.
A C Beynen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  56     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1986  
Date Detail:
Created Date:  1987-03-10     Completed Date:  1987-03-10     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  387-90     Citation Subset:  IM    
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MeSH Terms
Cholesterol / blood,  metabolism*
Cholesterol, Dietary / analysis,  pharmacology*
Dietary Fats / analysis,  pharmacology*
Liver / metabolism*
Mice, Inbred C57BL
Mice, Inbred Strains
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Dietary Fats; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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