Document Detail

Plasma lipoprotein pattern and decreased platelet function in type V hyperlipoproteinemia.
MedLine Citation:
PMID:  4077486     Owner:  NLM     Status:  MEDLINE    
Plasma lipid and lipoprotein pattern as well as platelet aggregation and [14C]serotonin release were studied in five male patients with primary Type V hyperlipoproteinemia and in age-matched healthy control subjects. Plasma very-low-density lipoprotein (VLDL) cholesterol, triglycerides (TG) and protein were significantly elevated in the patients, and this resulted in 54% and 32% increments in cholesterol:protein and TG:protein ratios, respectively. In both low-and high-density lipoproteins (LDL and HDL), the cholesterol:protein ratio was normal, but the TG:protein ratio increased threefold. In the patient VLDL, apolipoprotein (apo) E and the sialyzed apo C-III (C-III2) were elevated, but apo C-III0 was decreased; whereas in the patient HDL, sialyzed apo C-IIIs were lower than in the normal HDL. Platelet function was found to be decreased in our patients in comparison with the normal group. Upon incubation of plasma lipoproteins derived from both groups with normal washed platelets, all patient plasma lipoproteins caused decreased platelet function in comparison with the normal lipoproteins. This study indicates plasma lipoprotein abnormalities in Type V hyperlipoproteinemia and may suggest that depressed platelet aggregation and release in these patients are a result of this normal lipoprotein pattern.
M Aviram; J G Brook
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  21     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-02-20     Completed Date:  1986-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  898-904     Citation Subset:  IM    
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MeSH Terms
Apolipoprotein C-III
Apolipoproteins C / blood
Blood Platelets / physiology*
Cholesterol / blood
Hyperlipoproteinemia Type V / blood*
Lipoproteins / blood*
Middle Aged
Platelet Aggregation
Serotonin / secretion
Triglycerides / blood
Reg. No./Substance:
0/Apolipoprotein C-III; 0/Apolipoproteins C; 0/Lipoproteins; 0/Triglycerides; 50-67-9/Serotonin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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