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Plasma lipocalin-2 levels in pregnancy.
MedLine Citation:
PMID:  21504415     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To evaluate plasma Lipocalin-2 levels, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective case-control study. Setting. University hospital. Population. Pregnant women with pre-pregnancy body mass index >25kg/m(2) (over-weight) (n=29) and body mass index <25kg/m(2) (n=27), whose gestational ages were between 24-28weeks as study groups and non-pregnant controls with body mass index <25kg/m(2) (n=29). Methods. Plasma Lipocalin-2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Main outcome measures. Comparisons among the groups and correlations for Lipocalin-2 and the parameters of insulin resistance. Results. Plasma Lipocalin-2 levels among the pregnant women were significantly higher than those of the control group (p<0.001 for both group comparisons). Lipocalin-2 levels were significantly higher in the group with pre-pregnancy body mass index >25kg/m(2) compared to the group with pre-pregnancy body mass index <25kg/m(2) (p=0.003). Lipocalin-2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Conclusions. Lipocalin-2 was found to be higher in pregnant women especially when pre-pregnancy body mass index was more than 25kg/m(2) and it was correlated with markers of insulin resistance.
Authors:
Semra Cesur; Aykan Yucel; Volkan Noyan; Nevin Sagsoz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Kirikkale University, School of Medicine, Department of Obstetrics and Gynecology, Kirikkale, Turkey.
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