| Plasma lipocalin-2 levels in pregnancy. | |
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MedLine Citation:
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PMID: 21504415 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective. To evaluate plasma Lipocalin-2 levels, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective case-control study. Setting. University hospital. Population. Pregnant women with pre-pregnancy body mass index >25kg/m(2) (over-weight) (n=29) and body mass index <25kg/m(2) (n=27), whose gestational ages were between 24-28weeks as study groups and non-pregnant controls with body mass index <25kg/m(2) (n=29). Methods. Plasma Lipocalin-2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Main outcome measures. Comparisons among the groups and correlations for Lipocalin-2 and the parameters of insulin resistance. Results. Plasma Lipocalin-2 levels among the pregnant women were significantly higher than those of the control group (p<0.001 for both group comparisons). Lipocalin-2 levels were significantly higher in the group with pre-pregnancy body mass index >25kg/m(2) compared to the group with pre-pregnancy body mass index <25kg/m(2) (p=0.003). Lipocalin-2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Conclusions. Lipocalin-2 was found to be higher in pregnant women especially when pre-pregnancy body mass index was more than 25kg/m(2) and it was correlated with markers of insulin resistance. |
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Authors:
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Semra Cesur; Aykan Yucel; Volkan Noyan; Nevin Sagsoz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-19 |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: - ISSN: 1600-0412 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology. |
Affiliation:
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Kirikkale University, School of Medicine, Department of Obstetrics and Gynecology, Kirikkale, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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