Document Detail

Plasma lipocalin-2 levels in pregnancy.
MedLine Citation:
PMID:  21504415     Owner:  NLM     Status:  Publisher    
Objective. To evaluate plasma Lipocalin-2 levels, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective case-control study. Setting. University hospital. Population. Pregnant women with pre-pregnancy body mass index >25kg/m(2) (over-weight) (n=29) and body mass index <25kg/m(2) (n=27), whose gestational ages were between 24-28weeks as study groups and non-pregnant controls with body mass index <25kg/m(2) (n=29). Methods. Plasma Lipocalin-2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Main outcome measures. Comparisons among the groups and correlations for Lipocalin-2 and the parameters of insulin resistance. Results. Plasma Lipocalin-2 levels among the pregnant women were significantly higher than those of the control group (p<0.001 for both group comparisons). Lipocalin-2 levels were significantly higher in the group with pre-pregnancy body mass index >25kg/m(2) compared to the group with pre-pregnancy body mass index <25kg/m(2) (p=0.003). Lipocalin-2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Conclusions. Lipocalin-2 was found to be higher in pregnant women especially when pre-pregnancy body mass index was more than 25kg/m(2) and it was correlated with markers of insulin resistance.
Semra Cesur; Aykan Yucel; Volkan Noyan; Nevin Sagsoz
Related Documents :
11189235 - Construction of human insulin gene expression recombinant and its effect on blood gluco...
23260985 - Role of body mass index in acute charcot neuroarthropathy.
8914855 - Decreased neurotrophin-3 expression in skeletal muscles of streptozotocin-induced diabe...
10200585 - Overweight and increased diabetes susceptibility in neonatally insulin-treated adult rats.
17727625 - Aldose reductase is implicated in high glucose-induced oxidative stress in mouse embryo...
3310655 - Reversal of the exercise-induced increase in muscle permeability to glucose.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
Kirikkale University, School of Medicine, Department of Obstetrics and Gynecology, Kirikkale, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Restless legs syndrome in pregnancy is a frequent disorder with a good prognosis.
Next Document:  Can placental histology establish the timing of meconium passage during labor?