Document Detail


Plasma lipids and physicochemical properties of the erythrocyte plasma membrane throughout pregnancy.
MedLine Citation:
PMID:  15059156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The physiopathological relevance of plasma lipid concentrations is supported by the observation that they might affect the physicochemical properties of the plasma membrane of circulating cells and might be crucial in the pathological conditions complicating pregnancy. METHODS: Plasma and erythrocyte membrane lipid composition, membrane fluidity and function [membrane-bound enzyme sodium/potassium adenosine triphosphatase (Na+/K+-ATPase) activity] were studied in 24 healthy women in the nonpregnant condition and at 12, 24 and 38 weeks' gestation. RESULTS: The plasma showed an increase in total and high density lipoprotein (HDL) cholesterol, triglyceride (TG) and phospholipid (PL) levels. In the erythrocyte membrane we found the cholesterol/phospholipid (C/PL) ratio increased and the saturated to unsaturated fatty acid (FA) ratio (Sat/Unsat) significantly reduced; fluorescence polarization showed an initial increase during pregnancy and a progressive decrease afterwards; Na+/K+-ATPase activity was progressively reduced. CONCLUSIONS: A generalized alteration in the composition and function of the maternal erythrocyte membrane is present during a physiological pregnancy, and these modifications may involve a more complex physiopathogenetic mechanism.
Authors:
Andrea Luigi Tranquilli; Nelvio Cester; Stefano Raffaele Giannubilo; Alessandra Corradetti; Laura Nanetti; Laura Mazzanti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  83     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-02     Completed Date:  2004-05-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  443-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, School of Obstetrics, Polytechnic University of Marche, Ancona, Italy. tranquilli@univpm.it
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Cholesterol, HDL / blood,  metabolism
Erythrocyte Membrane / metabolism*
Female
Gestational Age
Humans
Longitudinal Studies
Membrane Lipids / metabolism
Phospholipids / blood,  metabolism
Pregnancy / blood,  metabolism*
Prospective Studies
Sodium-Potassium-Exchanging ATPase
Triglycerides / blood,  metabolism
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Membrane Lipids; 0/Phospholipids; 0/Triglycerides; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

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