Document Detail


Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy.
MedLine Citation:
PMID:  16394047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Intrahepatic cholestasis of pregnancy is associated with dyslipidemia, but the gestational lipid profile in relation to clinical diagnosis of the disease is unknown. The aim of this study was to undertake a detailed analysis of plasma lipids in women presenting with intrahepatic cholestasis of pregnancy and pruritus gravidarum. METHODS: Plasma lipid concentrations were assessed in nonfasting blood samples from 63 women with intrahepatic cholestasis of pregnancy (n = 54, recruited at the time of diagnosis, and n = 9, who later developed the disease), 43 women with pruritus gravidarum, and 26 healthy pregnant controls during pregnancy and at 4-6 weeks postpartum. RESULTS: Intrahepatic cholestasis of pregnancy was associated with an abnormal lipid profile. Low-density lipoprotein (LDL) cholesterol, apolipoprotein B-100, and total cholesterol concentrations were significantly raised during pregnancy in women with intrahepatic cholestasis of pregnancy compared with pruritus gravidarum and controls, and LDL-cholesterol was raised before clinical diagnosis. High-density lipoprotein cholesterol was lower in women with intrahepatic cholestasis of pregnancy compared with the pruritus gravidarum group. Ursodeoxycholic acid did not alter plasma lipid concentrations. CONCLUSION: Intrahepatic cholestasis is associated with dyslipidemia, which may contribute to the pathogenesis of the disease. The elevation of LDL cholesterol and reduction of high-density lipoprotein cholesterol before clinical diagnosis may prove to be a useful biomarker for the early identification of intrahepatic cholestasis of pregnancy and differentiation from pruritus gravidarum. LEVEL OF EVIDENCE: II-2.
Authors:
Anthony T Dann; Anna P Kenyon; Anthony S Wierzbicki; Paul T Seed; Andrew H Shennan; Rachel M Tribe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  107     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-05     Completed Date:  2006-03-02     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-14     Citation Subset:  AIM; IM    
Affiliation:
Division of Reproductive Health, Endocrinology and Development, King's College London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cholestasis, Intrahepatic / blood,  diagnosis*
Cholesterol, HDL / blood*
Cholesterol, LDL / blood*
Dyslipidemias / blood,  diagnosis*
Female
Gestational Age
Humans
Incidence
Lipid Metabolism / physiology
Maternal Age
Pregnancy
Pregnancy Complications / blood,  diagnosis*
Pregnancy Outcome*
Prenatal Care / methods
Probability
Risk Assessment
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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