| Plasma lipid peroxidation and totalantioxidant status among dyslipidaemic and hypertensive Nigerians with high risk of coronary heart disease. | |
| | |
MedLine Citation:
|
PMID: 19761169 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: The oxidative modification hypothesis of atherosclerosis predicts that low density lipoprotein-cholesterol (LDL-C) oxidation is an early event in atherosclerosis and that oxidized LDL-C contributes to atherogenesis OBJECTIVE: To determine a link, if any, between the plasma lipid peroxidation and total antioxidant status (TAS) among dyslipidemic and hypertensive Nigerian patients with high risk of coronary heart disease. METHODS: The study groups comprised 58 hypertensive adult Nigerians whose fasting plasma total cholesterol (TC) levels were > 5.5 mmol/L and with high risk coronary heart disease (CHD) lipid fraction i.e. 'the ratio of high density lipoprotein cholesterol to total cholesterol' (HDL-C/TC) < 0.13 were selected for the study. The control groups comprised 58 non hypertensive adult Nigerians with (HDL-C/TC) > 0.30. RESULTS: The mean +/- SD TAS level (1.02 +/- 0.15 mmol/L trolox) for males and (0.99 +/- 0.17 mmol/L) for females were significantly reduced (p < 0.05) compared to the controls; however (MDA) level (5.15 +/- 0.82 mmol/ml) for males and (5.06 +/- 0.73 mmol/ml) for females were significantly increased (p < 0.01) compared to the controls. The mean +/- SD plasma TC and LDL-C malonyl level (5.87 +/- 0.23 mmol/L and 4.65 +/- 0.34 mmol/L) were significantly increased (p < 0.01) in males hypertensive compared to the control. An inverse correlation between the TAS/TC(r = -0.53, p < 0.001) and TAS/LDL-C (r = -0.50, p < 0.001), however a direct correlation between the MDA/TC(r = 0.51, p < 0.001) and MDA/LDL-C (r = 0.48, p < 0.01) for males hypertensive were found. In female subjects the mean +/- SD plasma TC (5.95 +/- 0.13 mmol/L) and LDL-C (4.45 +/- 1.04 mmol/L) were significantly increased (p < 0.05) and (p < 0.01) respectively compared to the controls. Also in hypertensive females inverse correlation between the TAS/TC (r = -0.59, p < 0.001) and TAS/LDL-C (r = -.41, p < 0.01), and a direct correlation between the MDA/TC ( r= .48, p < 0.01) and MDA/LDL-C (r = 0.31, p < 0.05) were found. CONCLUSION: Since dyslipidaemia, hypertension and lipid peroxidation were directly relate to the severity of atherosclerosis, elimination of free radicals in the plasma before the peripheral tissues can take them up might reduce atherosclerosis. In view of our present findings, a management strategy aimed at simultaneously reducing lipid peroxidation and increasing total antioxidant status in dyslipidemic patients may be of benefit. |
| | |
Authors:
|
P S Ogunro; W O Balogun; F F Fadero; E S Idogun; S O Oninla; P O Elemile; A K Eziyi |
Related Documents
:
|
10501279 - Hyperlipidaemia management after primary coronary artery bypass surgery: a survey of pa... 18550349 - Polymorphisms in the cd36 gene modulate the ability of fish oil supplements to lower fa... 11755939 - Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoprot... 2372619 - Effectiveness and hazards of case finding for a high cholesterol concentration. 18570239 - Extract of black tea (pu-ehr) inhibits postprandial rise in serum cholesterol in mice, ... 8788319 - Cardiovascular risk profile in 38-year and 18-year-old men. contribution of body fat co... 1642689 - Non-cholesterol sterols, absorption and synthesis of cholesterol and apolipoprotein a-i... 1693649 - Modification of the core lipids of low density lipoproteins produces selective alterati... 21971629 - Carbohydrate content of post-operative diet influences the effect of vertical sleeve ga... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: West African journal of medicine Volume: 28 ISSN: 0189-160X ISO Abbreviation: West Afr J Med Publication Date: 2009 Mar |
Date Detail:
|
Created Date: 2009-09-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8301891 Medline TA: West Afr J Med Country: Nigeria |
Other Details:
|
Languages: eng Pagination: 87-91 Citation Subset: IM |
Affiliation:
|
Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology Osogbo, Nigeria. ogunrops@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The import of abdominal pain in adults with sickle cell disorder.
Next Document: Menstrual characteristics of secondary school girls in Ibadan, Nigeria.