| Plasma lipid and lipoprotein levels during the follicular and luteal phases of the menstrual cycle. | |
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MedLine Citation:
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PMID: 14764796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Estrogen levels are higher during the luteal compared with the follicular phase of the menstrual cycle. It was hypothesized that the luteal compared with the follicular phase has a lipid and lipoprotein profile associated with decreased coronary heart disease (CHD) risk. This was tested using well-defined data from healthy, well-characterized premenopausal Caucasian women under very controlled metabolic conditions. The percent differences in lipid, lipoprotein, and sex hormone levels between the follicular and luteal phases were estimated using generalized estimating equations after adjusting for age, body mass index, calendar time, and season. The low-density lipoprotein cholesterol (LDL-C) level was 6.2% lower (P = 0.015), and the total cholesterol/high-density lipoprotein cholesterol (HDL-C) and LDL-C/HDL-C ratios were 5.1% (P = 0.0006) and 8.4% (P = 0.002) lower, respectively, during the luteal phase. Levels of estradiol and other estrogens were significantly higher (by>100% each; P < 0.0001 in all cases) in the luteal phase. These findings support the study hypothesis. Fluctuations in levels of LDL-C and the total cholesterol/HDL-C and LDL-C/HDL-C ratios between menstrual cycle phases need to be considered in the screening and medical monitoring of premenopausal women, especially those with borderline levels. Although small, such fluctuations may prove to be clinically significant in the long run. Studies involving premenopausal women need to more clearly define and validate menstrual cycle phase in the design and interpretation of study results. |
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Authors:
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Junaidah B Barnett; Margo N Woods; Stefania Lamon-Fava; Ernst J Schaefer; Judith R McNamara; Donna Spiegelman; Ellen Hertzmark; Barry Goldin; Christopher Longcope; Sherwood L Gorbach |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 89 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-06 Completed Date: 2004-03-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 776-82 Citation Subset: AIM; IM |
Affiliation:
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Nutrition/Infection Unit, Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. junaidah.barnett@tufts.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholesterol, HDL / blood Cholesterol, LDL / blood Estradiol / blood Estrogens / blood Female Follicular Phase / blood* Humans Lipids / blood* Lipoproteins / blood* Luteal Phase / blood* Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR-00054/RR/NCRR NIH HHS; R37-CA-45128/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Estrogens; 0/Lipids; 0/Lipoproteins; 50-28-2/Estradiol |
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