| Plasma lipid alterations after total splenectomy, subtotal splenectomy and splenic auto-implants in rats. | |
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MedLine Citation:
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PMID: 18086114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: The relation between the spleen and lipid metabolism has not been properly studied. In order to contribute to the filling of this gap, in the present investigation we experimentally assessed the lipidogram of rats in the presence of the spleen, in asplenia, and after conservative spleen surgeries. METHODS: Fifty female Wistar rats of similar weight and age were divided into five groups submitted to the following procedures: group 1: control, with an intact spleen; group 2: sham operation; group 3: total splenectomy; group 4: subtotal splenectomy; and group 5: total splenectomy complemented with autogenous spleen tissue implants. Four months after the interventions, serum triglycerides, total cholesterol and fractions (very-low-density lipoprotein [VLDL]-cholesterol, low-density lipoprotein [LDL]-cholesterol, high-density lipoprotein [HDL]-cholesterol) were determined. The results for the four groups were compared by analysis of variance followed by the Tukey-Kramer test, with the level of significance set at P < 0.05. RESULTS: There were no differences between groups 1, 2, 4 and 5. In the animals submitted to total splenectomy, total cholesterol (P = 0.0151) and LDL-cholesterol fraction concentrations (P < 0.0001) were higher, whereas HDL-cholesterol fraction concentrations were lower (P = 0.0026) than those detected in the other groups. There was no difference in triglycerides (P = 0.1571) or VLDL-cholesterol (P = 0.2527) between groups. CONCLUSION: The spleen probably plays an important role in the lipid metabolism of female rats and total splenectomy may be related to changes in cholesterol control. It is possible that preservation of spleen tissue prevents such metabolic disorders. |
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Authors:
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Andy Petroianu; Denny Fm Veloso; Luiz R Alberti; Leonardo de Souza Vasconcellos |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-13 |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 23 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-08-14 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: e221-4 Citation Subset: IM |
Affiliation:
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Department of Surgery, Medicine School of the Federal University of Minas Gerais, Belo Horizonte, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / blood* Female Rats Rats, Wistar Spleen / metabolism*, surgery*, transplantation Splenectomy / methods* Time Factors Transplantation, Autologous Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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