Document Detail


Plasma levels and urinary excretion of amino acids by subjects with renal calculi.
MedLine Citation:
PMID:  19787430     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium phosphate stones, either pure or mixed with apatite. Some types of stones (namely oxalate and uric acid calculi) are mainly formed as a result of a metabolic deficiency that may affect the amino acid metabolism, and thus may be reflected in the urinary amino acid pattern. Data demonstrated clearly that there is a general tendency towards decreased amino acid excretions in all SFs with all types of stones. As a whole, one can observe a higher percentage of patients with calcium oxalate and phosphate calculosis, who have low urine excretions of amino acids; about 50% are the SFs with lower urine excretion of serine, glycine, taurine and i-leucine; the high percentage of patients with CaOX calculi shows lower urine excretions of tyrosine and ornithine.
Authors:
Stoyanka Slavcheva Atanassova; P Panchev; M Ivanova
Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-29
Journal Detail:
Title:  Amino acids     Volume:  38     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1277-82     Citation Subset:  IM    
Affiliation:
Department of Urology, Alexandrov's University Hospital, Medical University, G. Sofiisky Blvd 1, 1431, Sofia, Bulgaria. stoyana_atanassova@abv.bg
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acids / blood,  metabolism*,  urine
Apatites / metabolism
Calcium Oxalate / metabolism
Chromatography, High Pressure Liquid
Female
Humans
Kidney Calculi / blood,  metabolism*,  urine
Magnesium Compounds / metabolism
Male
Middle Aged
Phosphates / metabolism
Uric Acid / metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Apatites; 0/Magnesium Compounds; 0/Phosphates; 15490-91-2/struvite; 25454-23-3/Calcium Oxalate; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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