Document Detail


Plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 are correlated with the presence of transplant coronary artery disease in cardiac transplant recipients.
MedLine Citation:
PMID:  9230149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemostatic factors are involved in the pathogenesis of native coronary artery disease. However, their role in transplant coronary artery disease is less established. To assess the role of hemostatic factors in transplant coronary artery disease we studied 52 consecutive cardiac transplant patients. The presence of transplant coronary artery disease was determined by angiography. Plasma levels of tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), von Willebrand Factor (vWF), and fibrin D-dimer were determined by enzyme-linked immunosorbent assays. Serum lipids were measured by enzymatic methods. Patients with transplant coronary artery disease had higher circulating t-PA (8.6 +/- 0.8 vs. 5.4 +/- 0.6 ng/ml, p = 0.021) and PAI-1 antigen concentrations (38.0 +/- 3.4 vs 25.8 +/- 2.2 ng/ml, p = 0.037). t-PA and PAI-1 antigen concentrations correlated with the severity of angiographic disease (R = 0.34; p = 0.014 for t-PA, and R = 0.45; p = 0.001 for PAI-1). Serum cholesterol levels were higher in patients with transplant coronary artery disease (221 +/- 7.6 vs 191 +/- 9.2 mg/dl, p = 0.039). Serum triglycerides were also higher in patients with transplant coronary artery disease by angiography (246 +/- 38.3 vs 139 +/- 20.8 mg/dl, p = 0.050). Multivariate analysis identified t-PA antigen (p = 0.003) and triglyceride levels (p = 0.038) as independent predictors for the presence of transplant coronary artery disease. We conclude that cardiac transplant patients with evidence of transplant coronary artery disease on coronary angiography have altered hemostatic function which is reflected by elevated levels of circulating t-PA and PAI-1 antigens. The interaction of the hemostatic system and serum lipids in the development of transplant coronary artery disease warrants further study.
Authors:
M K Warshofsky; H S Wasserman; W Wang; P Teng; R Sciacca; M Apfelbaum; A Schwartz; R E Michler; D M Mancini; P J Cannon; L E Rabbani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  80     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-07     Completed Date:  1997-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Cholesterol / blood
Coronary Disease / blood*
Female
Fibrin Fibrinogen Degradation Products / analysis
Heart Transplantation / physiology*
Humans
Male
Plasminogen Activator Inhibitor 1 / blood*
Tissue Plasminogen Activator / blood*
Triglycerides / blood
von Willebrand Factor / analysis
Grant Support
ID/Acronym/Agency:
HL-21006/HL/NHLBI NIH HHS; K11 HL-02578/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Plasminogen Activator Inhibitor 1; 0/Triglycerides; 0/fibrin fragment D; 0/von Willebrand Factor; 57-88-5/Cholesterol; EC 3.4.21.68/Tissue Plasminogen Activator

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