| Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention. | |
| | |
MedLine Citation:
|
PMID: 18617477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: Thromboxane A2 (TXA2) is a key mediator of platelet activation and aggregation, and an important mediator of platelet-induced coronary artery constriction. We sought to investigate whether baseline plasma levels of TXA2 are associated with coronary no-reflow after primary percutaneous coronary intervention (PPCI). METHODS AND RESULTS: A total of 47 consecutive patients (age, 62.5 +/- 12.7; male sex, 76.6%) admitted to our hospital for a first ST-segment elevation myocardial infarction and undergoing PPCI within 12 h of onset of symptoms were enrolled. Admission TXA2 plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). Angiographic no-reflow was defined as a final TIMI flow of <or=2 or final TIMI flow of 3 with a myocardial blush grade of <2, whereas ST-segment resolution from baseline value of <or=50% was used as ECG index of no-reflow. At multivariable analysis TXA2 plasma levels, endothelin-1 (ET-1) plasma levels, and left anterior descending coronary artery (LAD) as culprit vessel were significant predictors of angiographic no-reflow (P = 0.04), whereas TXA2 and ET-1 plasma levels were the only independent predictors of lack of ST-segment resolution (P = 0.013 and 0.04, respectively). Of note, TXA2 tertiles were independent predictors of both angiographic no-reflow and lack of ST-segment resolution (OR, 3.5; 95% CI, 1.1-11; P = 0.03 and OR, 3; 95% CI, 1.3-7; P = 0.01, respectively). CONCLUSION: TXA2 is an independent indicator of no-reflow that occurs after PPCI. This observation may open new therapeutic opportunity in the setting of PPCI. |
| | |
Authors:
|
Giampaolo Niccoli; Simona Giubilato; Eleonora Russo; Cristina Spaziani; Andrea Leo; Italo Porto; Antonio M Leone; Francesco Burzotta; Silvia Riondino; Fabio Pulcinelli; Luigi M Biasucci; Filippo Crea |
Related Documents
:
|
9643687 - Angina pectoris caused by coronary microvascular spasm. 6808817 - Regional coronary artery dilation response in variant angina. 14643917 - Yawning despite trismus in a patient with locked-in syndrome caused by a thrombosed meg... 7116587 - Pathophysiology of coronary artery spasm. 12574747 - Bilateral pulmonary artery compression and obstruction by tumor: diagnosis by unusual d... 10751767 - Influence of residual stenosis in determining restenosis after cutting balloon angiopla... |
Publication Detail:
|
Type: Journal Article Date: 2008-07-10 |
Journal Detail:
|
Title: European heart journal Volume: 29 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-08-04 Completed Date: 2008-12-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
|
Languages: eng Pagination: 1843-50 Citation Subset: IM |
Affiliation:
|
Institute of Cardiology, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy. gniccoli73@hotmail.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Transluminal, Percutaneous Coronary
/
adverse effects* Biological Markers / blood Coronary Angiography Coronary Circulation / drug effects Electrocardiography Endothelin-1 / blood Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Myocardial Infarction / blood, therapy* No-Reflow Phenomenon / blood*, etiology Risk Assessment Thromboxane A2 / blood* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Endothelin-1; 57576-52-0/Thromboxane A2 |
| Comments/Corrections | |
Comment In:
|
Eur Heart J. 2008 Aug;29(15):1795-7
[PMID:
18617478
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical impact of an inter-hospital transfer strategy in patients with ST-elevation myocardial infa...
Next Document: The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening v...