Document Detail

Plasma levels of soluble Fas during normal pregnancy.
MedLine Citation:
PMID:  11223701     Owner:  NLM     Status:  MEDLINE    
The Fas/Fas ligand system could reportedly help to identify a mechanism for maternal immunotolerance of the fetus in human pregnancy. However, there are few reports on soluble Fas (sFas) which is an inhibitor of apoptosis during normal pregnancy. Therefore, ascertaining plasma sFas levels during pregnancy would be of interest. The subjects studied were 10 nonpregnant healthy women and 20 healthy pregnant women in the first and third trimester with singleton gestations. The plasma sFas was measured by sandwich enzyme-linked immunosorbent assay. The mean concentration of sFas was significantly decreased in normal pregnant women in the first trimester compared to age-matched control subjects, and it did not differ significantly between normal pregnant women in the third trimester and age-matched control subjects. From these results, we presume that the decreased plasma sFas plays an important role in maternal immunotolerance in the first trimester of pregnancy.
K Hoshimoto; M Hayashi; T Ohkura
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  51     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  96-8     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami-Koshigaya, Koshigaya, Saitama, Japan.
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MeSH Terms
Apoptosis / physiology
Biological Markers / blood
Enzyme-Linked Immunosorbent Assay
Fas Ligand Protein
Immunocompetence / physiology*
Membrane Glycoproteins / blood*
Pregnancy / blood*
Pregnancy Trimester, First
Pregnancy Trimester, Third
Reference Values
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins

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