| Plasma levels of soluble Fas during normal pregnancy. | |
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MedLine Citation:
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PMID: 11223701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Fas/Fas ligand system could reportedly help to identify a mechanism for maternal immunotolerance of the fetus in human pregnancy. However, there are few reports on soluble Fas (sFas) which is an inhibitor of apoptosis during normal pregnancy. Therefore, ascertaining plasma sFas levels during pregnancy would be of interest. The subjects studied were 10 nonpregnant healthy women and 20 healthy pregnant women in the first and third trimester with singleton gestations. The plasma sFas was measured by sandwich enzyme-linked immunosorbent assay. The mean concentration of sFas was significantly decreased in normal pregnant women in the first trimester compared to age-matched control subjects, and it did not differ significantly between normal pregnant women in the third trimester and age-matched control subjects. From these results, we presume that the decreased plasma sFas plays an important role in maternal immunotolerance in the first trimester of pregnancy. |
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Authors:
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K Hoshimoto; M Hayashi; T Ohkura |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 51 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 96-8 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami-Koshigaya, Koshigaya, Saitama, Japan. hkazu@dokkyomed.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apoptosis / physiology Biological Markers / blood Enzyme-Linked Immunosorbent Assay Fas Ligand Protein Female Humans Immunocompetence / physiology* Membrane Glycoproteins / blood* Pregnancy / blood* Pregnancy Trimester, First Pregnancy Trimester, Third Probability Reference Values Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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