Document Detail

Plasma levels of retinoids, carotenoids and tocopherols in patients with mild obstructive sleep apnoea.
MedLine Citation:
PMID:  19761534     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: OSA is associated with increased incidence of cardiovascular diseases. Pathogenic mechanisms of vascular diseases include thickened vascular walls due to the increased number of smooth muscle cells (SMC). Retinoic acid (RA) suppresses the growth of SMC, and reduced retinoid levels are associated with vascular diseases. Oxidant signalling promotes SMC growth, thus antioxidant levels may also influence the development of cardiovascular diseases. The present study tested the hypothesis that plasmas from OSA patients contain altered levels of retinoids, carotenoids and tocopherols.
METHODS: Plasma samples were taken before and after sleep from patients with OSA (mostly mild) without known cardiovascular diseases and from control subjects. Levels of retinoids, carotenoids and tocopherols were measured using sensitive gas chromatograph-mass spectrometry and high pressure liquid chromatography methods and total antioxidant capacity was assessed fluorometrically.
RESULTS: Results showed that plasmas from patients with OSA had significantly lower retinyl palmitate and 9-cis RA compared with control subjects, while levels of retinol, all-trans RA and 13-cis RA were indifferent. All-transbeta-carotene and 9-cisbeta-carotene were also lower in OSA patients. Levels of all-trans RA and 13-cis RA in OSA patients were reduced after sleep compared with before sleep. OSA patients showed significantly higher delta-tocopherol compared with controls. Treatment of cultured human vascular SMC with post-sleep OSA patient plasmas promoted cell growth, but not in controls.
CONCLUSIONS: Mild OSA exhibits altered levels of specific retinoids, carotenoids and tocopherols, which may be markers and/or mediators for the increased susceptibility of patients to vascular diseases.
Regina M Day; Ismael A Matus; Yuichiro J Suzuki; Kyung-Jin Yeum; Jian Qin; Ah-Mee Park; Vivek Jain; Tunay Kuru; Guangwen Tang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-09-16
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  14     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-13     Completed Date:  2010-02-24     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1134-42     Citation Subset:  IM    
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA.
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MeSH Terms
Antioxidants / metabolism
Biological Markers / blood
Carotenoids / blood*
Case-Control Studies
Cell Proliferation
Cells, Cultured
Middle Aged
Muscle, Smooth, Vascular / pathology
Oxidative Stress / physiology
Prospective Studies
Retinoids / blood*
Retrospective Studies
Risk Factors
Severity of Illness Index*
Sleep Apnea, Obstructive / blood*,  physiopathology
Tocopherols / blood*
Vascular Diseases / epidemiology
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Retinoids; 1406-66-2/Tocopherols; 36-88-4/Carotenoids

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