| Plasma levels of retinoids, carotenoids and tocopherols in patients with mild obstructive sleep apnoea. | |
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MedLine Citation:
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PMID: 19761534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: OSA is associated with increased incidence of cardiovascular diseases. Pathogenic mechanisms of vascular diseases include thickened vascular walls due to the increased number of smooth muscle cells (SMC). Retinoic acid (RA) suppresses the growth of SMC, and reduced retinoid levels are associated with vascular diseases. Oxidant signalling promotes SMC growth, thus antioxidant levels may also influence the development of cardiovascular diseases. The present study tested the hypothesis that plasmas from OSA patients contain altered levels of retinoids, carotenoids and tocopherols. METHODS: Plasma samples were taken before and after sleep from patients with OSA (mostly mild) without known cardiovascular diseases and from control subjects. Levels of retinoids, carotenoids and tocopherols were measured using sensitive gas chromatograph-mass spectrometry and high pressure liquid chromatography methods and total antioxidant capacity was assessed fluorometrically. RESULTS: Results showed that plasmas from patients with OSA had significantly lower retinyl palmitate and 9-cis RA compared with control subjects, while levels of retinol, all-trans RA and 13-cis RA were indifferent. All-transbeta-carotene and 9-cisbeta-carotene were also lower in OSA patients. Levels of all-trans RA and 13-cis RA in OSA patients were reduced after sleep compared with before sleep. OSA patients showed significantly higher delta-tocopherol compared with controls. Treatment of cultured human vascular SMC with post-sleep OSA patient plasmas promoted cell growth, but not in controls. CONCLUSIONS: Mild OSA exhibits altered levels of specific retinoids, carotenoids and tocopherols, which may be markers and/or mediators for the increased susceptibility of patients to vascular diseases. |
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Authors:
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Regina M Day; Ismael A Matus; Yuichiro J Suzuki; Kyung-Jin Yeum; Jian Qin; Ah-Mee Park; Vivek Jain; Tunay Kuru; Guangwen Tang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-09-16 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: 14 ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2010-02-24 Revised Date: 2010-11-02 |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
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Languages: eng Pagination: 1134-42 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. rday@usuhs.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / metabolism Biological Markers / blood Carotenoids / blood* Case-Control Studies Cell Proliferation Cells, Cultured Female Humans Male Middle Aged Muscle, Smooth, Vascular / pathology Oxidative Stress / physiology Prospective Studies Retinoids / blood* Retrospective Studies Risk Factors Severity of Illness Index* Sleep Apnea, Obstructive / blood*, physiopathology Tocopherols / blood* Vascular Diseases / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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HL67340/HL/NHLBI NIH HHS; HL72844/HL/NHLBI NIH HHS; HL73929/HL/NHLBI NIH HHS; R01 HL073929-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Retinoids; 1406-66-2/Tocopherols; 36-88-4/Carotenoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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