| Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients. | |
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MedLine Citation:
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PMID: 22012040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study aimed to examine the association between different inflammatory markers and specific clinical endpoints in patients with febrile neutropenia. METHOD: We prospectively evaluated the expression of procalcitonin (PCT), interleukin 8 (IL-8), induced protein-10, tumor necrosis factor alpha (TNF-α), two soluble TNF-α receptors (sTNF-R I and sTNF-R II), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha, and eotaxin in 37 episodes of febrile neutropenia occurring in 31 hospitalized adult onco-hematologic patients. Peripheral blood samples were collected in the morning at inclusion (day of fever onset) and on days 1, 3, and 7 after the onset of fever. Approximately 2-3 ml of plasma was obtained from each blood sample and stored at -80 °C. RESULTS: The sTNF-R II level at inclusion (day 1), the PCT level on the day of fever onset, and the change (day 3 - day 1) in the IL-8 and eotaxin levels were significantly higher in patients who died during the 28-day follow-up. A requirement for early adjustment of antimicrobial treatment was associated with higher day 3 levels of IL-8, sTNF-R II, PCT, and MCP-1. CONCLUSION: Procalcitonin, sTNF-R II, IL-8, MCP-1, and eotaxin could potentially be used to assess the risk of death and the requirement for early adjustment of antimicrobial treatment in febrile, neutropenic onco-hematologic patients. The levels of the other markers showed no association with any of the evaluated endpoints. |
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Authors:
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Letícia Carvalho Neuenschwander; Henrique Bittencourt; Ana Flávia Tibúrcio Ribeiro; Antônio Lúcio Teixeira; Mauro M Teixeira; Jairo Cerqueira Teixeira; Vandack Nobre |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinics (São Paulo, Brazil) Volume: 66 ISSN: 1980-5322 ISO Abbreviation: Clinics (Sao Paulo) Publication Date: 2011 |
Date Detail:
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Created Date: 2011-10-20 Completed Date: 2012-02-22 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 101244734 Medline TA: Clinics (Sao Paulo) Country: Brazil |
Other Details:
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Languages: eng Pagination: 1699-705 Citation Subset: IM |
Affiliation:
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Postgraduate Course in Infectious Diseases and Tropical Medicine, Internal Medicine Department, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte/MG, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood C-Reactive Protein / metabolism Calcitonin / blood* Cause of Death Chemokine CCL11 / blood Chemokine CCL2 / blood Chemokine CCL3 / blood Epidemiologic Methods Female Humans Inflammation / blood Interleukin-6 / blood Interleukin-8 / blood Male Middle Aged Neutropenia / blood*, mortality Prospective Studies Protein Precursors / blood* Receptors, Tumor Necrosis Factor, Type I / blood Time Factors Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chemokine CCL11; 0/Chemokine CCL2; 0/Chemokine CCL3; 0/Interleukin-6; 0/Interleukin-8; 0/Protein Precursors; 0/Receptors, Tumor Necrosis Factor, Type I; 0/TNFRSF1A protein, human; 0/Tumor Necrosis Factor-alpha; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
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