Document Detail


Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients.
MedLine Citation:
PMID:  22012040     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study aimed to examine the association between different inflammatory markers and specific clinical endpoints in patients with febrile neutropenia.
METHOD: We prospectively evaluated the expression of procalcitonin (PCT), interleukin 8 (IL-8), induced protein-10, tumor necrosis factor alpha (TNF-α), two soluble TNF-α receptors (sTNF-R I and sTNF-R II), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha, and eotaxin in 37 episodes of febrile neutropenia occurring in 31 hospitalized adult onco-hematologic patients. Peripheral blood samples were collected in the morning at inclusion (day of fever onset) and on days 1, 3, and 7 after the onset of fever. Approximately 2-3 ml of plasma was obtained from each blood sample and stored at -80 °C.
RESULTS: The sTNF-R II level at inclusion (day 1), the PCT level on the day of fever onset, and the change (day 3 - day 1) in the IL-8 and eotaxin levels were significantly higher in patients who died during the 28-day follow-up. A requirement for early adjustment of antimicrobial treatment was associated with higher day 3 levels of IL-8, sTNF-R II, PCT, and MCP-1.
CONCLUSION: Procalcitonin, sTNF-R II, IL-8, MCP-1, and eotaxin could potentially be used to assess the risk of death and the requirement for early adjustment of antimicrobial treatment in febrile, neutropenic onco-hematologic patients. The levels of the other markers showed no association with any of the evaluated endpoints.
Authors:
Letícia Carvalho Neuenschwander; Henrique Bittencourt; Ana Flávia Tibúrcio Ribeiro; Antônio Lúcio Teixeira; Mauro M Teixeira; Jairo Cerqueira Teixeira; Vandack Nobre
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-20     Completed Date:  2012-02-22     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1699-705     Citation Subset:  IM    
Affiliation:
Postgraduate Course in Infectious Diseases and Tropical Medicine, Internal Medicine Department, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte/MG, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
C-Reactive Protein / metabolism
Calcitonin / blood*
Cause of Death
Chemokine CCL11 / blood
Chemokine CCL2 / blood
Chemokine CCL3 / blood
Epidemiologic Methods
Female
Humans
Inflammation / blood
Interleukin-6 / blood
Interleukin-8 / blood
Male
Middle Aged
Neutropenia / blood*,  mortality
Prospective Studies
Protein Precursors / blood*
Receptors, Tumor Necrosis Factor, Type I / blood
Time Factors
Tumor Necrosis Factor-alpha / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Chemokine CCL11; 0/Chemokine CCL2; 0/Chemokine CCL3; 0/Interleukin-6; 0/Interleukin-8; 0/Protein Precursors; 0/Receptors, Tumor Necrosis Factor, Type I; 0/TNFRSF1A protein, human; 0/Tumor Necrosis Factor-alpha; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein
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