Document Detail

Plasma levels of polymorphonuclear elastase and myeloperoxidase after uphill walking and downhill running at similar energy cost.
MedLine Citation:
PMID:  1330946     Owner:  NLM     Status:  MEDLINE    
This study was designed to compare the effects of eccentric and concentric exercises on blood polymorphonuclear neutrophil count (nPMN) and plasma levels of myeloperoxidase ([MPO]) and elastase ([EL]) used as markers of neutrophil (PMN) activation. Ten healthy male subjects underwent 2 periods of exercise of 20 min duration each at 60% VO2max on an inclined treadmill. They initially walked up a 5% grade (UW). Ten days later they ran downhill on a 20% grade (RD). Blood samples were collected 10 min before and immediately after exercise. A postexercise sample was drawn after 20 min recovery. Both exercise bouts were accompanied by a similar and significant (p < 0.01) increase of 33% in nPMN above resting values. Baseline nPMN values were reached after 20 min recovery. There were no significant changes in [MPO] and [EL] following UW. In contrast, RD was followed by significant increases (p < 0.001) in [MPO] (+97%) and [EL] (+70%) above resting levels. While [MPO] returned to its pre-exercise level after 20 min recovery, [EL] remained significantly elevated (p < 0.05). These results clearly demonstrate the importance of the eccentric component of muscle contraction in exercise-induced PMN activation.
G Camus; J Pincemail; M Ledent; A Juchmès-Ferir; M Lamy; G Deby-Dupont; C Deby
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of sports medicine     Volume:  13     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-17     Completed Date:  1992-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
FNRS, Laboratory of Human Applied Physiology, ISEPK, University of Liège, Belgium.
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MeSH Terms
Energy Metabolism / physiology*
Exercise Test
Leukocyte Count
Muscle Contraction / physiology
Neutrophils / enzymology*
Oxygen Consumption / physiology
Pancreatic Elastase / blood*
Peroxidase / blood*
Running / physiology*
Walking / physiology*
Reg. No./Substance:
EC; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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