| Plasma levels of polymorphonuclear elastase and myeloperoxidase after uphill walking and downhill running at similar energy cost. | |
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MedLine Citation:
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PMID: 1330946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to compare the effects of eccentric and concentric exercises on blood polymorphonuclear neutrophil count (nPMN) and plasma levels of myeloperoxidase ([MPO]) and elastase ([EL]) used as markers of neutrophil (PMN) activation. Ten healthy male subjects underwent 2 periods of exercise of 20 min duration each at 60% VO2max on an inclined treadmill. They initially walked up a 5% grade (UW). Ten days later they ran downhill on a 20% grade (RD). Blood samples were collected 10 min before and immediately after exercise. A postexercise sample was drawn after 20 min recovery. Both exercise bouts were accompanied by a similar and significant (p < 0.01) increase of 33% in nPMN above resting values. Baseline nPMN values were reached after 20 min recovery. There were no significant changes in [MPO] and [EL] following UW. In contrast, RD was followed by significant increases (p < 0.001) in [MPO] (+97%) and [EL] (+70%) above resting levels. While [MPO] returned to its pre-exercise level after 20 min recovery, [EL] remained significantly elevated (p < 0.05). These results clearly demonstrate the importance of the eccentric component of muscle contraction in exercise-induced PMN activation. |
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Authors:
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G Camus; J Pincemail; M Ledent; A Juchmès-Ferir; M Lamy; G Deby-Dupont; C Deby |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of sports medicine Volume: 13 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-12-17 Completed Date: 1992-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 443-6 Citation Subset: IM |
Affiliation:
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FNRS, Laboratory of Human Applied Physiology, ISEPK, University of Liège, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Energy Metabolism / physiology* Exercise Test Humans Leukocyte Count Male Muscle Contraction / physiology Neutrophils / enzymology* Oxygen Consumption / physiology Pancreatic Elastase / blood* Peroxidase / blood* Running / physiology* Walking / physiology* |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.7/Peroxidase; EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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