Document Detail


Plasma levels of nitrite/nitrate and platelet cGMP levels are decreased in patients with atrial fibrillation.
MedLine Citation:
PMID:  9409310     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with atrial fibrillation have been reported to exhibit abnormal hemostasis. Since nitric oxide (NO) exerts antithrombotic effects and attenuates platelet function, we evaluated two indicators of plasma NO levels, the plasma levels of nitrite and nitrate (NOx), and the levels of cGMP in platelets. We also examined whether indicators of plasma NO levels were associated with abnormalities in parameters related to platelet function, blood coagulation, and fibrinolysis. We evaluated 45 patients with chronic sustained atrial fibrillation (33 men and 12 women, age range 63 +/- 2 years) compared with 45 sex- and age- (+/- 2 years) matched nonhospitalized subjects with sinus rhythm. There were no significant differences between the two groups in the incidence of risk factors for stroke except for ischemic heart disease or in echocardiographic parameters. Plasma levels of NOx measured using the Greiss reagent (mean [interquartile range]: 15.6 [9.5 to 25.7] versus 24.1 [14.2 to 40.8] mumol/L, n = 45) and the platelet cGMP levels (0.33 [0.16 to 0.67] versus 0.63 [0.31 to 1.29] pmol/10(9) platelets, n = 9) were significantly (P < .05) lower in the patients with atrial fibrillation than in the control subjects. Plasma levels of D-dimer, beta-thromboglobulin, and fibrinogen were significantly (P < .05) higher in the patients with atrial fibrillation. The two groups did not differ as to the plasma levels of tissue plasminogen activator or plasminogen activator inhibitor-1. Our findings suggest that a decrease in plasma NO levels may account for the hemostatic abnormalities observed in patients with atrial fibrillation.
Authors:
T Minamino; M Kitakaze; H Sato; H Asanuma; H Funaya; Y Koretsune; M Hori
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  17     ISSN:  1079-5642     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-22     Completed Date:  1998-01-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3191-5     Citation Subset:  IM    
Affiliation:
First Department of Medicine, Osaka University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Atrial Fibrillation / blood*,  complications,  epidemiology
Blood Platelets / chemistry*
Blood Proteins / analysis
Cerebrovascular Disorders / epidemiology,  prevention & control
Comorbidity
Cyclic GMP / blood*
Diabetes Mellitus / epidemiology
Echocardiography
Female
Fibrinogen / analysis
Hemodynamics
Humans
Hyperlipidemias / epidemiology
Hypertension / epidemiology
Male
Middle Aged
Myocardial Ischemia / epidemiology
Nitrates / blood*
Nitric Oxide / blood*,  physiology
Nitrites / blood*
Risk Factors
Smoking / epidemiology
Thrombophilia / blood,  epidemiology,  etiology*
beta-Thromboglobulin / analysis
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Nitrates; 0/Nitrites; 0/beta-Thromboglobulin; 10102-43-9/Nitric Oxide; 7665-99-8/Cyclic GMP; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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