Document Detail


Plasma levels of pipecolic acid, both L- and D-enantiomers, in patients with chronic liver diseases, especially hepatic encephalopathy.
MedLine Citation:
PMID:  10509899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pipecolic acid is regarded as a gamma-aminobutyric acid receptor agonist. Stereochemical studies of pipecolic acid were performed in patients with chronic liver diseases. Plasma D- and L-pipecolic acid were significantly elevated in 15 liver cirrhotic patients with no history of hepatic encephalopathy (1.05+/-0.24 micromol/l, 1.58+/-0.13 micromol/l, p < 0.01) and in 27 patients with chronic hepatic encephalopathy (1.58+/-0.50 micromol/l, 2.38+/-0.58 micromol/l, p<0.001) compared to 15 normal subjects. In seven patients with chronic hepatic encephalopathy orally treated with kanamycin, plasma pipecolic acid significantly decreased (D-acid: before 1.62+/-0.23 micromol/l, after 0.61+/-0.15 micromol/l; p<0.01, L-acid: before 2.43-0.52 micromol/l, after 2.23+/-0.11 micromol/l; p< 0.05). These results suggest that plasma pipecolic acid, particularly D-acid, is produced from D-lysine by intestinal bacteria in liver cirrhotic patients and that pipecolic acid could be involved in the pathogenesis of hepatic encephalopathy.
Authors:
T Fujita; Y Amuro; T Hada; K Higashino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  287     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-20     Completed Date:  1999-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-109     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chronic Disease
Female
Hepatic Encephalopathy / blood*
Humans
Liver Cirrhosis / blood*
Male
Middle Aged
Pipecolic Acids / blood*
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Stereoisomerism
Chemical
Reg. No./Substance:
0/Pipecolic Acids; 535-75-1/pipecolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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