Document Detail

Plasma levels of matrix metalloproteinase-9 are independently associated with psychosocial factors in a middle-aged normal population.
MedLine Citation:
PMID:  19196809     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the association between psychosocial factors and circulating levels of matrix metalloproteinase-9 (MMP-9) in a normal population sample. Psychosocial factors have been associated with inflammatory markers and are of prognostic significance for coronary artery disease (CAD). The degrading enzyme MMP-9 is upregulated in inflammatory processes and hypothesized to play a role in the rupture of atherosclerotic plaques. METHODS: A total of 402 participants (50% women), aged 45 to 69 years, were drawn randomly from a normal population. Psychosocial instruments covered depression (Center for Epidemiological Studies Depression Questionnaire, CES-D), vital exhaustion, hostile affect, cynicism, mastery, self-esteem, sense of coherence (SOC), emotional support, and social integration. Plasma MMP-9 was measured by an enzyme-linked immunosorbent assay method. Linear regression models were adjusted for age, sex, known CAD, rheumatoid arthritis, cancer, cardiovascular risk factors including C-reactive protein and ongoing medication. RESULTS: After full adjustment, there were independent associations of elevated MMP-9 levels with CES-D (+2.9 ng/ml per SD, p = .02), hostile affect (+3.0 ng/ml per SD, p = .02), cynicism (+3.5 ng/ml per SD, p = .006), and SOC (-2.5 ng/ml per SD, p = .046). A principal component analysis extracted three components. The first was mainly extracted from CES-D, vital exhaustion, self-esteem, mastery, and SOC; the second was mainly extracted from hostile affect and cynicism. Both were independently associated with MMP-9 (p = .02, p = .04) when run in the same model. CONCLUSIONS: MMP-9 levels were associated with psychosocial factors in a middle-aged normal population sample, independently of traditional risk factors. The findings may constitute a possible link between psychosocial factors and cardiovascular risk.
Peter Garvin; Lennart Nilsson; John Carstensen; Lena Jonasson; Margareta Kristenson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-05
Journal Detail:
Title:  Psychosomatic medicine     Volume:  71     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-15     Completed Date:  2009-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-300     Citation Subset:  IM    
Department of Medical and Health Sciences, Division of Community Medicine, Linköping University, Linköping 581 83, Sweden.
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MeSH Terms
Coronary Artery Disease / blood*
Depressive Disorder, Major / blood*,  epidemiology,  psychology
Matrix Metalloproteinase 9 / blood*
Middle Aged
Self Concept
Social Support
Reg. No./Substance:
EC Metalloproteinase 9

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