| Plasma levels of matrix metalloproteinase-8 in patients with carotid atherosclerosis. | |
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MedLine Citation:
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PMID: 20626027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P<0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P<0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. |
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Authors:
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Tamara Djurić; Maja Zivković; Aleksandra Stanković; Ana Kolaković; Djole Jekić; Vesna Selaković; Dragan Alavantić |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical laboratory analysis Volume: 24 ISSN: 1098-2825 ISO Abbreviation: J. Clin. Lab. Anal. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801384 Medline TA: J Clin Lab Anal Country: United States |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Affiliation:
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Vinca Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics, Belgrade, Serbia. tamariska@vinca.rs |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Analysis of Variance Aspartate Aminotransferases / blood Biological Markers / blood C-Reactive Protein / analysis Carotid Artery Diseases / diagnosis, enzymology* Case-Control Studies Creatinine / blood Enzyme-Linked Immunosorbent Assay Female Humans Male Matrix Metalloproteinase 8 / blood* Middle Aged Risk Factors Statistics, Nonparametric Urea / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 57-13-6/Urea; 60-27-5/Creatinine; 9007-41-4/C-Reactive Protein; EC 2.6.1.1/Aspartate Aminotransferases; EC 3.4.24.34/Matrix Metalloproteinase 8 |
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