| Plasma levels of immunoreactive corticotrophin in patients with Cushing's syndrome. | |
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MedLine Citation:
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PMID: 4301887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma levels of immunoreactive corticotrophin (A.C.T.H.) have been determined in 56 patients with Cushing's syndrome by means of a homologous radioimmunoassay. In untreated Cushing's disease (bilateral adrenal hyperplasia due to excessive A.C.T.H. secretion from the pituitary) plasma values ranged from 40 to 200 mumug./ml., between 8 and 10 a.m., compared with a range in normal subjects of 12 to 60 mumug./ml. Considerably raised levels, often above 2,000 mumug./ml., were found in patients with Cushing's disease after bilateral adrenalectomy. A.C.T.H. concentrations were usually higher in patients with bilateral adrenal hyperplasia associated with ectopic A.C.T.H. production than in patients with untreated Cushing's disease; whereas plasma A.C.T.H. was undetectable in the presence of an adrenocortical tumour. All patients with Cushing's syndrome failed to show the normal circadian rhythm of circulating A.C.T.H. levels. |
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Authors:
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G M Besser; J Landon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British medical journal Volume: 4 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1968 Nov |
Date Detail:
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Created Date: 1969-01-17 Completed Date: 1969-01-17 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 552-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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blood Adrenal Glands / physiopathology Adrenalectomy Adrenocorticotropic Hormone / biosynthesis, blood* Bronchial Neoplasms / metabolism Circadian Rhythm Colonic Neoplasms / metabolism Cushing Syndrome / blood*, surgery Humans Pancreatic Neoplasms / metabolism Radioimmunoassay Stomach Neoplasms / metabolism |
| Chemical | |
Reg. No./Substance:
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9002-60-2/Adrenocorticotropic Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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