Document Detail

Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study.
MedLine Citation:
PMID:  12823999     Owner:  NLM     Status:  MEDLINE    
Pregnancy is proposed to be a Th2 phenomenon, where Th2 cytokines inhibit Th1 responses to improve foetal survival. The importance of interleukin-10 (IL-10), an immunomodulatory cytokine produced by Th2 cells, in the maintenance of normal pregnancy is becoming increasingly apparent. In a longitudinal case-control study, the physiological effect of pregnancy on plasma IL-10 was investigated. The plasma concentration of IL-10 was determined using an ELISA technique in 99 pregnant women sampled at 12, 20 and 35 weeks of gestation, 38 non-pregnant control subjects sampled in parallel and in a subgroup of women sampled at 3 days post-partum (n, pregnant 21, non-pregnant 21). Plasma IL-10 was significantly higher in pregnant women at 12, 20 and 35 weeks of gestation (p<0.05, p<0.01 and p<0.0001, respectively), and in mothers post-delivery (p<0.01) when compared to non-pregnant control subjects. Furthermore, there was no significant effect of gestational time on IL-10 concentration. Results from the current study suggest that elevated IL-10 is a physiological consequence of normal healthy pregnancy. These findings help clarify previous conflicting results and establish a range for plasma levels of IL-10 in normal healthy pregnancy.
V A Holmes; J M W Wallace; W S Gilmore; P McFaul; H D Alexander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytokine     Volume:  21     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-06-25     Completed Date:  2004-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, BT52 1SA, Northern Ireland, Coleraine, UK.
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MeSH Terms
Adjuvants, Immunologic / blood
Interleukin-10 / blood*
Longitudinal Studies
Postpartum Period
Pregnancy / blood,  immunology*
Reference Values
Reg. No./Substance:
0/Adjuvants, Immunologic; 130068-27-8/Interleukin-10

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