Document Detail

Plasma levels of free tissue factor pathway inhibitor in patients with various thyroid disorders.
MedLine Citation:
PMID:  14512089     Owner:  NLM     Status:  MEDLINE    
Various coagulation abnormalities occur in thyroid disorders and its range may vary from subclinical laboratory abnormalities to clinically significant disorders of coagulation. Tissue factor pathway inhibitor (TFPI), which inhibits the initial reaction of tissue factor mediated coagulation pathway, is reported to be increased in patients with Graves disease (GD) in one study. Hyperthyroid (n=10), hypothyroid (n=10) and subclinical hypothyroid (n=10) patients and control cases (n=16) were evaluated for free and total tissue factor pathway inhibitor (tTFPI), plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) levels in disease and euthyroid states. Free TFPI levels were significantly higher in hyperthyroid patients compared with the control group and subclinic hypothyroid patients (p<0.001), but not with hypothyroid patients (p>0.05). After the euthyroid state was obtained in the hyperthyroid group, the levels of total TFPI (p<0.05), free TFPI (fTFPI) (p<0.005), t-PA (p<0.005) and PAI-1 (p<0.02) decreased significantly. In hyperthyroid patients, there was a strong correlation between thyroid functions and free TFPI levels. In conclusion, we hypothesize that coagulation abnormalities seen in thyroid disorders cannot be explained directly with the impaired fibrinolytic activity but also with the elevated fTFPI levels. Both increased plasma fTFPI and PAI-1 levels could be markers of the peripheral activity of thyroid hormones.
Mehmet Ali Ozcan; Abdurrahman Cömlekçi; Fatih Demirkan; Faize Yüksel; Ismail Sari; Tevfik Demir; Güner Hayri Ozsan; Gonca Orük; Sena Yeşil; Bülent Undar
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  110     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-09-26     Completed Date:  2004-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-7     Citation Subset:  IM    
Division of Hematology-Oncology, Department of Internal Medicine, School of Medicine, Dokuz Eylul University, 35340 Inciralti, Izmir, Turkey.
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MeSH Terms
Anticoagulants / blood
Hyperthyroidism / blood
Hypothyroidism / blood
Lipoproteins / blood*
Middle Aged
Plasminogen Activator Inhibitor 1 / blood
Thyroid Diseases / blood*,  pathology
Tissue Plasminogen Activator / blood
Reg. No./Substance:
0/Anticoagulants; 0/Lipoproteins; 0/Plasminogen Activator Inhibitor 1; 0/lipoprotein-associated coagulation inhibitor; EC Plasminogen Activator

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