Document Detail

Plasma levels of coagulation inhibitors, fibrinolytic markers and platelet-derived growth factor-AB in patients with failed hip prosthesis.
MedLine Citation:
PMID:  14620976     Owner:  NLM     Status:  MEDLINE    
We studied the plasma levels of coagulation inhibitors, of fibrinolysis and PDGF-AB, in patients with aseptic loosening of the hip replacement. 23 patients having loose hip prostheses were compared to patients having 15 stable hip prostheses, and 26 undergoing primary hip replacement. The levels of the coagulation inhibitors antithrombin III and protein C were determined by chromogenic assays. Fibrinolysis was evaluated by the changes in fibrin degradation products (D-dimer), determined by enzyme immunoassay, and in the plasminogen activator inhibitor-1 (PAl-1), by enzymatic assay. PDGF-AB was determined by enzyme immunoassay. In patients with failed prostheses, we found fibrinolysis activation, as shown by a statistically significant increase in D-dimer and a significant decrease of PAI-1. No significant differences were obseved in antithrombin III, protein C, and PDGF-AB. PAI-1 and D-dimer assays in failed prostheses may be useful for the pathogenetic evaluation, because the continuous inflammatory stimulus associated with fibrin deposition may also affect the systemic levels.
Elisabetta Cenni; Lucia Savarino; Nicola Baldini; Roberto Rotini; Alessandro Marinelli; Michele Mieti; Armando Giunti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  74     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2003-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  IM    
Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy.
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MeSH Terms
Aged, 80 and over
Antithrombin III / analysis*
Fibrin Fibrinogen Degradation Products / analysis*
Middle Aged
Platelet-Derived Growth Factor / analysis*
Prosthesis Failure
Protein C / analysis*
Recombinant Proteins / analysis*
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Platelet-Derived Growth Factor; 0/Protein C; 0/Recombinant Proteins; 0/platelet-derived growth factor AB; 9000-94-6/Antithrombin III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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