Document Detail

Plasma levels of the beta chemokine regulated upon activation, normal T cell expressed, and secreted (RANTES) correlate with severe brain injury.
MedLine Citation:
PMID:  18301198     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The expression of the beta chemokine RANTES (regulated upon activation, normal T cell expressed, and secreted) has previously been shown to be elevated after traumatic brain injury (TBI) in animal models, but it was unknown whether the plasma level of RANTES was predictive of TBI in critically injured trauma patients. METHODS: A prospective study was conducted on 108 critically ill trauma patients. Patients were stratified by radiologic diagnosis of TBI. Severe TBI was classified as the presence of diffuse axonal injury, midline shift, or herniation based on admission head computed tomography findings. Serum levels were evaluated at admission and hospital day 7. RANTES was measured using Luminex multiplex assays. RESULTS: Fifty-four patients with and without TBI were compared. Severe TBI was diagnosed in 23 of the 54 TBI patients (43%) and mild/moderate TBI was found in 31 (57%) patients. The mean age of the study population was 43 +/- 20 years with a mean Injury Severity Score of 29 +/- 14. There was no significant difference between groups in age, sex, and Injury Severity Score. At admission, RANTES was significantly higher in patients with severe brain injury than in non-TBI patients (mean 1,339 pg/mL vs. 708 pg/mL, p = 0.046), and there was a trend toward significance when comparing patients with severe versus mild/moderate brain injury (mean 1,339 pg/mL vs. 752 pg/mL, p = 0.069). There was no statistically significant difference on day 7. CONCLUSIONS: RANTES was a significant early marker of severe TBI in critically injured trauma patients, consistent with animal models. Future research on the role of RANTES in the pathogenesis of human TBI is warranted.
Kimberly Lumpkins; Grant V Bochicchio; Bradley Zagol; Kristian Ulloa; J Marc Simard; Stacey Schaub; Walter Meyer; Thomas Scalea
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  64     ISSN:  1529-8809     ISO Abbreviation:  J Trauma     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-27     Completed Date:  2008-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-61     Citation Subset:  AIM; IM    
Division of Clinical Outcomes Research, R. Adams Cowley Shock Trauma Center, Baltimore, Maryland, USA.
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MeSH Terms
Analysis of Variance
Biological Markers / blood
Brain Injuries / blood,  classification,  diagnosis*
Chemokine CCL5 / blood*
Critical Illness
Injury Severity Score
Middle Aged
Prospective Studies
Regression Analysis
Trauma Severity Indices
Reg. No./Substance:
0/Biological Markers; 0/Chemokine CCL5

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