Document Detail

Plasma levels of atrial natriuretic peptide during myocardial ischemia induced by percutaneous transluminal coronary angioplasty or dynamic exercise.
MedLine Citation:
PMID:  2522719     Owner:  NLM     Status:  MEDLINE    
To study the effects of myocardial ischemia on plasma atrial natriuretic peptide (ANP) levels, immunoreactive ANP levels in the pulmonary artery (ANP-PA) and femoral vein (ANP-V) were measured before and during percutaneous transluminal coronary angioplasty (PTCA). Ten patients (group 1), seven of whom had no symptoms during PTCA, maintained a normal mean pulmonary capillary wedge pressure (PCWP) of less than or equal to 13 mm Hg during PTCA, whereas five patients (group 2), all of whom had symptoms and signs of ischemia during PTCA, had an increased PCWP of greater than or equal to 20 mm Hg. ANP levels did not differ significantly between the two groups before PTCA, but ANP-PA (p less than 0.02) and ANP-V (p less than 0.01) during PTCA were higher in group 2 than in group 1. ANP-V at rest and during exercise was measured in 11 patients with and 14 patients without anginal symptoms and ischemic ST changes on the ECG during exercise. The values did not change significantly in either group, and there were no difference between the groups. Thus myocardial ischemia during PTCA may lead to left ventricular dysfunction serious enough to increase PCWP and subsequently plasma ANP levels in some patients. Myocardial ischemia induced by dynamic exercise seems to be unrelated to significant changes in the plasma ANP level.
M J Ikäheimo; H J Ruskoaho; K E Airaksinen; H V Huikuri; U R Korhonen; P J Leppäluoto; M O Tuominen; J T Takkunen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  117     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-03     Completed Date:  1989-05-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  837-41     Citation Subset:  AIM; IM    
Department of Medicine, University of Oulu, Finland.
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MeSH Terms
Angioplasty, Balloon*
Atrial Natriuretic Factor / blood*
Coronary Disease / blood*,  physiopathology,  therapy
Femoral Vein
Middle Aged
Physical Exertion*
Pulmonary Artery
Pulmonary Wedge Pressure
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

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