Document Detail


Plasma levels of atrial natriuretic peptide during myocardial ischemia induced by percutaneous transluminal coronary angioplasty or dynamic exercise.
MedLine Citation:
PMID:  2522719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the effects of myocardial ischemia on plasma atrial natriuretic peptide (ANP) levels, immunoreactive ANP levels in the pulmonary artery (ANP-PA) and femoral vein (ANP-V) were measured before and during percutaneous transluminal coronary angioplasty (PTCA). Ten patients (group 1), seven of whom had no symptoms during PTCA, maintained a normal mean pulmonary capillary wedge pressure (PCWP) of less than or equal to 13 mm Hg during PTCA, whereas five patients (group 2), all of whom had symptoms and signs of ischemia during PTCA, had an increased PCWP of greater than or equal to 20 mm Hg. ANP levels did not differ significantly between the two groups before PTCA, but ANP-PA (p less than 0.02) and ANP-V (p less than 0.01) during PTCA were higher in group 2 than in group 1. ANP-V at rest and during exercise was measured in 11 patients with and 14 patients without anginal symptoms and ischemic ST changes on the ECG during exercise. The values did not change significantly in either group, and there were no difference between the groups. Thus myocardial ischemia during PTCA may lead to left ventricular dysfunction serious enough to increase PCWP and subsequently plasma ANP levels in some patients. Myocardial ischemia induced by dynamic exercise seems to be unrelated to significant changes in the plasma ANP level.
Authors:
M J Ikäheimo; H J Ruskoaho; K E Airaksinen; H V Huikuri; U R Korhonen; P J Leppäluoto; M O Tuominen; J T Takkunen
Related Documents :
16675499 - The plasma atrial natriuretic peptide response to arm and leg exercise in humans: effec...
20099699 - B-type natriuretic peptide and tissue doppler for predicting symptoms on treadmill exer...
1943729 - Effects of cocaine, exercise, and resting conditions on plasma corticosterone and catec...
10405119 - Brain norepinephrine changes with simulated weightlessness and relation to exercise tra...
9185749 - Impairment of renal function during moderate physical exercise in cirrhotic patients wi...
2331039 - Relation of plasma norepinephrine and sympathetic traffic during hypotension in humans.
11905959 - Effects of alpha-tocopherol, beta-carotene and ascorbic acid on oxidative, hormonal and...
17596269 - Leisure time activity and new onset of wheezing during adolescence.
24471129 - Effects of a pre-exercise meal on plasma growth hormone response and fat oxidation duri...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  117     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-03     Completed Date:  1989-05-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  837-41     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Oulu, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Angioplasty, Balloon*
Atrial Natriuretic Factor / blood*
Coronary Disease / blood*,  physiopathology,  therapy
Femoral Vein
Humans
Middle Aged
Physical Exertion*
Pulmonary Artery
Pulmonary Wedge Pressure
Chemical
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Angina preceding myocardial infarction and residual coronary narrowing after intracoronary thromboly...
Next Document:  Effects of intravenous metoprolol on global and regional left ventricular function after coronary ar...