Document Detail

Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases.
MedLine Citation:
PMID:  19006524     Owner:  NLM     Status:  MEDLINE    
AIM: The endothel dysfunction in early life may play a role in developmental programming of cardiovascular morbidity. The changes of dimethylarginines' plasma levels during the first month among preterm infants and their determinants had been investigated in our study. METHODS: Twenty preterm infants of healthy mothers were studied. Mean (+/-SD) birth weight and gestational age were 919.5 +/- 235.5 g and 26.7 +/- 1.6 weeks, respectively. Blood samples were taken by venipuncture at the 3rd, 7th, 14th, 21st and 28th days. Plasma concentrations of L-arginine, asymmetric and symmetric dimethylarginine (SDMA) were measured by liquid chromatography-mass spectrometry method, evaluated by multivariate linear regression analysis. RESULTS: L-arginine (p < 0.001) and asymmetric dimethylarginine (ADMA) levels (p < 0.001) were positively associated with postnatal age. ADMA levels were negatively correlated with gestational age (p = 0.007), dopamine-need on the 3rd day of life (p = 0.015) and late infection (p = 0.038). The higher birth weight was associated with higher L-arginine (p = 0.052) and ADMA (p = 0.002) concentrations. The dopamine-need on the 7th day of life had a significant effect on postnatal elevation of SDMA levels (p = 0.035). CONCLUSION: The progressive increase of ADMA levels described by our study among preterm infants suggests that early endothel dysfunction may take part in developmental programming of chronic adult diseases.
Gabriella Vida; Endre Sulyok; Orsolya Lakatos; Tibor Ertl; Jens Martens-Lobenhoffer; Stefanie M Bode-Böger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-11
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  98     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  437-41     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, Pécs, Hungary.
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MeSH Terms
Arginine / analogs & derivatives*,  blood
Cardiovascular Diseases / etiology
Chronic Disease
Diabetes Mellitus, Type 2 / etiology
Infant, Low Birth Weight / blood*
Infant, Newborn
Infant, Premature / blood*
Metabolic Syndrome X / etiology
Reg. No./Substance:
30315-93-6/N,N-dimethylarginine; 74-79-3/Arginine

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