| Plasma levels of aldosterone precursors (including the 18-hydroxylated compounds in this synthesis pathway)--a tool for the analysis of adrenal disorders? | |
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MedLine Citation:
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PMID: 1966563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Some current ideas concerning the 18-hydroxylated corticosteroids (18-hydroxycorticosterone and 18-hydroxydeoxycorticosterone) and the other steroids of the mineralocorticosteroid pathway from deoxycorticosterone (DOC) are reviewed. Then, some recent findings from our own laboratory, obtained during the analysis of all aldosterone precursors from DOC in various adrenal disorders, such as enzyme deficiencies, and particularly adrenal masses detected in patients from various hospitals in France are discussed. The findings reported here show that these specialized assays can be valuable tools to determine adrenal function in complex cases. |
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Authors:
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B Aupetit-Faisant |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hormone research Volume: 34 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 1990 |
Date Detail:
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Created Date: 1991-10-24 Completed Date: 1991-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 142-50 Citation Subset: IM |
Affiliation:
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Service de Biochimie, CHU Pitié-Salpêtrière, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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18-Hydroxycorticosterone
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blood 18-Hydroxydesoxycorticosterone / blood Adrenal Gland Diseases / diagnosis* Adrenal Glands / drug effects, metabolism Adrenocorticotropic Hormone / physiology Aldosterone / biosynthesis* Angiotensin II / physiology Circadian Rhythm / physiology Dopamine / physiology Humans Ketoconazole / pharmacology Metyrapone / pharmacology Mixed Function Oxygenases / deficiency, physiology Posture Sodium / physiology |
| Chemical | |
Reg. No./Substance:
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0/18-Hydroxydesoxycorticosterone; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 54-36-4/Metyrapone; 561-65-9/18-Hydroxycorticosterone; 65277-42-1/Ketoconazole; 7440-23-5/Sodium; 9002-60-2/Adrenocorticotropic Hormone; EC 1.-/Mixed Function Oxygenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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