Document Detail

Plasma levels of adhesion molecules ICAM-1 and VCAM-1 in athletes with sickle cell trait with or without alpha-thalassemia during endurance exercise and recovery.
MedLine Citation:
PMID:  19029634     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to examine the effects of endurance exercise on circulating vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in sickle cell trait (SCT) athletes with or without alpha-thalassemia. Five athletes with SCT, 7 athletes with both SCT and alpha-thalassemia (SCTAT) and 8 control athletes (CONT) performed an incremental test on cycloergometer followed 72 hours later by a 60-min endurance exercise with a workload set at 70% P(peak) (peak power). We assessed levels of sICAM-1, sVCAM-1 and TNF-alpha at rest, immediately after endurance exercise and 1, 2, and 24 hours of recovery. Although, CONT and SCTAT groups exhibited similar basal plasma levels of adhesion molecules and TNF-alpha, SCT group had higher sVCAM-1 basal concentrations. No significant variation in sVCAM-1, sICAM-1 and TNF-alpha was measured following endurance exercise. Consequently, sVCAM-1 remained elevated in the SCT group after exercise and during the recovery period. In conclusion, our findings support the concept that SCT athletes might be at risk for microcirculatory disturbances, but these adhesive processes were not further impaired in response to endurance exercise. In addition, alpha-thalassemia co existing trait may be protective both at rest and after endurance exercise in SCT subjects.
Geraldine Monchanin; Laura D Serpero; Philippe Connes; Julien Tripette; Dieudonné Wouassi; Alain Francina; Raphael Massarelli; David Gozal; Patrice Thiriet; Cyril Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  40     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  89-97     Citation Subset:  IM    
EA 647 Center of Research and Innovation on Sports, Claude Bernard University of Lyon 1, and Unity of Hemoglobin Molecular Pathology, Edouard Herriot Hospital, Lyon, France.
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MeSH Terms
Intercellular Adhesion Molecule-1 / blood*
Physical Endurance*
Sickle Cell Trait / blood*,  physiopathology
Time Factors
Tumor Necrosis Factor-alpha / blood
Vascular Cell Adhesion Molecule-1 / blood*
alpha-Thalassemia / blood*,  physiopathology
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

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