Document Detail


Plasma levels of SP1-like immunoreactive material (SP1) and progesterone throughout pregnancy and following RU 486-induced early abortion in the cynomolgus monkey (Macaca fascicularis).
MedLine Citation:
PMID:  2693485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A human-SP1 immunoassay was used to detect SP1-like material (SP1) in the plasma of cynomolgus monkeys. In 27 females remaining non-pregnant during a mating period of 4 months, SP1 was occasionally detected at a mean concentration of 2.5 ng/ml. In 14 non-pregnant females of subsequent proven fertility, SP1 was detected 20 days following unfertile mating at a mean concentration of 4.8 ng/ml in 86% of cycles. At day 20 of proven pregnancies, SP1 was at 12 ng/ml in 93% of these animals. SP1 levels during pregnancy increased in two steps, a slow rise between days 20 and 50, followed by an abrupt rise between days 50 and 60 and afterwards a plateau at 600 ng/ml. Seven other pregnant monkeys received 10 mg/kg of the antiprogestin RU 486 at 28 days. Four aborted and the others continued their gestation. SP1 was always dramatically depressed by this treatment; in animals with abortion failure, it remained at a low concentration for 3 months, then the normal concentration range was recovered. The assay of SP1-like material does not allow early diagnosis of pregnancy, however, it remains interesting as a follow-up parameter after 60 days. Also, antiprogestins appear to be useful tools to analyse the metabolism of SP1.
Authors:
G Germain; T Mignot; P Bischof; M Mouren; L Cédard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  4     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-03-15     Completed Date:  1990-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  975-80     Citation Subset:  IM    
Affiliation:
U262 INSERM, Maternité Baudelocque, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced*
Animals
Female
Gestational Age
Half-Life
Immunoenzyme Techniques
Macaca fascicularis
Mifepristone / blood,  pharmacology*
Pregnancy
Pregnancy Proteins / metabolism*
Pregnancy, Animal / blood*
Pregnancy-Specific beta 1-Glycoproteins / metabolism*
Progesterone / blood*
Radioimmunoassay
Chemical
Reg. No./Substance:
0/Pregnancy Proteins; 0/Pregnancy-Specific beta 1-Glycoproteins; 57-83-0/Progesterone; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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